Can a Three-Drug cocktail boost Radiation's power against a rare lymphoma?
NCT ID NCT04366128
First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time
Summary
This trial is testing whether combining three drugs—camrelizumab, apatinib, and pegaspargase—with radiation therapy can improve outcomes for people with early-stage natural killer/T-cell lymphoma, a rare type of cancer. The study includes about 61 patients with stage IE or IIE disease who have not received prior treatment. The main goal is to see how many patients achieve a complete response (cancer disappearance) after 24 weeks of treatment, with secondary goals of measuring overall response, survival, and progression-free survival at two years.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- A combination of three drugs (camrelizumab, apatinib, and pegaspargase) given alongside radiation therapy
- What this could lead to
- If successful, this combination could become a more effective first-line treatment for early-stage NK/T-cell lymphoma, potentially improving complete response rates and long-term survival.
- What could go wrong
- This is an early-phase trial with a small number of participants, so results may not be conclusive. The combination of drugs and radiation may cause significant side effects, and the treatment may not work for everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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61 people
The number who actually took part.
- Started
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Apr 2020
- Finished
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Dec 2024
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients who meet the WHO 2016 diagnostic criteria for NK/T-cell lymphoma by biopsy histopathology, immunohistochemistry and EBER. * The primary site is in the nasal cavity or upper gastrointestinal tract. The de novo diagnosed patient has at least one objective and evaluable lesion. * Stage IE / IIE disease according to Lugano 2014 lymphoma staging system. * ECOG score 0-3. * The laboratory examination within 1 week before entering the group meets the following conditions: 1. Blood routine test: neutrophil count≥1.0 × 10\^9/L, Hemoglobin≥80g/L, Platelet≥50 × 10\^9/L. 2. Coagulation routine: plasma fibrinogen ≥ 1.0g / L. 3. Liver function: Alanine aminotransferase, aspartate aminotransferase and total bilirubin ≤ 2 times the upper limit of normal value. 4. Renal function: Creatinine is normal. 5. Refers to oxygen saturation\> 93%. 6. Cardiac function: Left ventricular ejection fraction ≥50%, electrocardiogram does not suggest any acute myocardial infarction, arrhythmia or atrioventricular block above 1 degree * Signed informed consent. * Voluntarily follow the research protocol, follow-up plan, laboratory and auxiliary examinations. Exclusion Criteria: * accompanied with HCV or HIV infection, HBV-infected patients who also receive antiviral treatment are not excluded. * Severe infection requires ICU treatment. * Serious complications such as hemophagocytic syndrome, DIC, etc. * Impairment of important organ functions: such as respiratory failure, chronic congestive heart failure with NYHA grade ≥3, decompensated liver or kidney dysfunction, hypertension and diabetes that cannot be controlled despite active treatment. * Have a history of autoimmune diseases, have disease activity in the last 6 months, and are still taking oral immunosuppressive therapy within the past three months, with a daily dose of oral prednisone greater than 10 mg. * Pregnant and lactating women. * Those who are known to be allergic to drugs in the CAPA regimen. * Patients with other tumors who need surgery or chemotherapy within 6 months. * Other experimental drugs are being used. * The investigators believe that other clinical conditions (including medical history or the presence of comorbidities) of the patient will significantly increase the risk of the subject when using the study treatment drugs.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Department of Hematology, Xinhua hospital
Shanghai, Shanghai Municipality, 200092, China
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Shanghai Eye Ear Nose and Throat Hospital, Fudan University
Shanghai, Shanghai Municipality, 200000, China
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Sun Yat-sen University
Guangzhou, Guangdong, 510060, China
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