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Could your blood predict jaw pain? new study investigates cannabinoid receptors

NCT ID NCT06405646

Knowledge-focused Sponsor: Wroclaw Medical University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study explores whether the levels of certain receptors (CB1, CB2, TRPV-1) in the blood are linked to chronic orofacial pain from jaw muscles. Researchers will compare 102 adults with and without this pain, using blood tests and clinical exams. The goal is to understand how these receptors, which bind to cannabis-like compounds, might influence pain risk and severity.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help identify biological markers for chronic orofacial pain, potentially leading to better diagnosis or targeted treatments.
What could go wrong
This is an observational study with only 102 participants, so results may not apply to everyone. It measures receptor levels, not treatments, so direct benefits are uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 102 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2025

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with suspicion of Chronic Orofacial Pain of Muscle Origin referred to the Wroclaw Medical University. Healthy controls.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * age over 18, under 80 * the presence of chronic pain in the muscles of the masticatory system, which lasts for more than 3 months in accordance with the international criteria included in ICOP-1. Exclusion Criteria: * people under 18 years of age * pregnant or breastfeeding women, * obese people, * people with active cancer, * people with severe systemic diseases, including genetic and neurological diseases, * people with severe mental illnesses and taking psychoactive substances, people who are taking or have taken antidepressants and/or myorelaxants and/or other drugs that affect neuromuscular activity in the last 12 months * people addicted to alcohol, drugs and other psychoactive substances * condition after craniofacial injuries

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Conditions

The condition(s) this trial relates to.

Facial Pain headache disorder Myalgia myofascial pain syndrome Tension-Type Headache

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Headache, tension Headaches muscular Muscle pain Myalgia Orofacial pain

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Wroclaw Medical University

    Wroclaw, 50-425, Poland

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