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Can smelling mugwort oil lift depression? new study investigates

NCT ID NCT07384312

Symptom relief Sponsor: Dongdong Qin Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether inhaling cang-ai volatile oil (mugwort oil) for one hour daily could help ease depression. 60 people with depression were randomly assigned to receive either mugwort oil or bergamot oil. Researchers used brain imaging and depression questionnaires to measure changes after one month.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
cang-ai volatile oil (mugwort essential oil)
What this could lead to
If it works, this could point toward a natural, inhaled treatment for depression symptoms.
What could go wrong
This is a small, early study with no blinding or placebo control, so results may not be reliable. The effect may be no better than the bergamot oil comparator.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

60 people

The number who actually took part.

Started

Oct 2023

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 26 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion： 1. Meets the diagnostic criteria for depressive episodes as outlined in the fifth edition (revised) of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). 2. Meets the diagnostic criteria for depression syndrome as defined in Part 1: Diseases of the Terminology for Clinical Diagnosis and Treatment in Traditional Chinese Medicine, issued by the National Administration of Traditional Chinese Medicine in 2023. 3. Scores on the 21-item Beck Depression Inventory (BDI) range from 10 to 15; scores on the 24-item Hamilton Depression Rating Scale (HAMD) range from 8 to 20. 4. Has a normal olfactory function, no history of allergic or respiratory diseases, aged 18-26 years. 5. At least one week prior to assessment, has not used antidepressants, other psychotropic medications, electroconvulsive therapy, or undergone transcranial magnetic stimulation or other physical therapies. 6. Exhibits depressive symptoms persisting for more than two weeks. 7. Right-handed. 8. Approved by the hospital ethics committee; all participants volunteer and have provided written informed consent. Exclusion ： 1. Strict exclusion of individuals with a history of schizophrenia, alcohol dependence, or substance abuse. 2. Presence of organic brain disease, endocrine disorders, or depression secondary to other mental illnesses. 3. A score of ≥3 points on the suicidal item of the Hamilton Depression Rating Scale. 4. Pregnant or lactating women, or those with a history of manic or hypomanic episodes. 5. Family history of monomorphic or bipolar affective disorder.

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Conditions

The condition(s) this trial relates to.

depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Depression disorder

Contacts and locations

Locations

  • Yunnan University of Chinese Medicine

    Kunming, Yunnan, 650500, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.