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Can a glimpse of the eye reveal What's happening in the lungs?

NCT ID NCT05847894

Diagnosis Sponsor: Zhongshan Ophthalmic Center, Sun Yat-sen University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time

Summary

This study is exploring whether artificial intelligence can analyze eye images to help diagnose lung diseases. Researchers will collect eye and lung examination data from 10,000 people with and without pulmonary conditions. By comparing the two, they aim to see if eye scans could serve as a new, non-invasive screening tool for early detection and better understanding of lung disease.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Ophthalmic examination combined with artificial intelligence analysis
What this could lead to
If successful, this could lead to a non-invasive, quick eye scan that helps detect lung diseases early, potentially improving outcomes through earlier intervention.
What could go wrong
The trial is exploratory and relies on AI accuracy, which may not be sufficient for clinical use. Eye-based diagnosis is an emerging field, and results may not generalize to all populations or disease types.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 10,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2020

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population was recruited from people who visited the cooperative medical unit for lung screening, and from people who were recruited through publicity at the unit and in the community.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Those aged ≥18 years; or those aged \<18 years who can cooperate with the relevant examination and are accompanied and informed by a guardian; * People with respiratory-related diseases who were to undergo pulmonary examination, or those who volunteered to participate in the trial through publicity recruitment; * expected survival time of 3 months or more; * Those with no previous serious underlying disease and no history of serious eye disease; * Those who can cooperate with ophthalmologic and pulmonary-related examinations and have regular follow-up examinations; * Those who gave informed consent to the study prior to the trial and voluntarily signed the informed consent form; * Other conditions that can be included in the study as judged by the investigator. Exclusion Criteria: * Patients who are unable to complete ophthalmology or pulmonary-related examinations and regular follow-ups due to serious diseases, trauma or surgery (serious ophthalmology diseases such as extremely poor vision that cannot be fixed, ocular atrophy, severe refractive interstitial clouding that prevents fundus photography, etc.); * People with poor compliance due to various reasons such as alcohol or drug dependence, or mental disorders; * Those without informed consent; * Other conditions judged by the investigator to be unsuitable for participation in the trial.

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Conditions

The condition(s) this trial relates to.

lung disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Artificial intelligence Ophthalmological diagnostic techniques Pulmonary diseases

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    4 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Guangzhou Kindness Health Care Center (Guangzhou Jiubang Shanxin Clinic Ltd)

    RECRUITING

    Guangzhou, Guangdong, China

  • Shenzhen Third People's Hospital

    RECRUITING

    Shenzhen, Guangdong, China

  • Zhongshan Ophthalmic Center, Sun Yat-sen University

    RECRUITING

    Guangzhou, Guangdong, 510060, China

  • the First Affiliated Hospital of Guangzhou Medical University

    RECRUITING

    Guangzhou, Guangdong, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.