Zapping away chemo brain: new hope for cancer survivors?

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Women or men with a history of non-metastatic cancer who have completed definitive curative cancer therapy * Received cytotoxic chemotherapy as a part of their therapy for cancer and at least one month has passed since the final cytotoxic chemotherapy treatment * ≥ 18 years of age at time of cancer diagnosis and receipt of chemotherapy * Patients must report subjective symptoms of "chemo-brain" (memory loss, difficulty with concentration, word-finding difficulties) with a FACT-Cog perceived cognitive impairment score \< 60 * Ability to sign informed consent and comply with study procedures Exclusion Criteria: * Patients with a recurrence of cancer or those with current metastatic disease * Patients with a history or current diagnosis of brain metastasis * Patients with a history or current diagnosis of a primary brain tumor * Patients with a history of brain surgery or brain radiation * Patients receiving maintenance systemic therapy for cancer, other than endocrine therapy * Patients who cannot produce or request adequate medical record documentation to ensure they meet inclusion and exclusion criteria * Women who are currently pregnant * History of childhood cancer or receipt of chemotherapy in childhood (\<age 18). Developmental insult to the PFC, can be associated with long-term, durable and sometime debilitating cognitive deficits. Hence, we avoid any cognitive confounds that maybe related to this issue. * Patients with a weight over 250 lbs., as these patients would not fit in the MRI scanner used in the protocol * Patients who require benzodiazepines for MRI due to claustrophobic anxiety * Patients with chest wall tissue expanders or other retained 7 Tesla MRI-incompatible metal. Any other specific contraindication to TMS or MRI not already listed above, including: * (a) any implanted device in the head, neck or upper body (e.g. cochlear implant, cranial or other electrodes, pacemaker or defibrillator, medication pump, stent, aneurysm clip, etc.) * (b) personal history of seizures or epilepsy, personal history of multiple concussions or unexplained loss of consciousness. This will be determined by physician judgement * History of adverse reaction to previous TMS or MRI exposure * Active substance use disorder in the past 6 months, excluding tobacco use disorder, as diagnosed by study physicians