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Caffeine may sharpen your Brain's reward learning, small study suggests

NCT ID NCT05325502

Knowledge-focused Sponsor: Yu-Shiuan Lin Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether caffeine can improve how people learn from rewards. Thirty-six healthy adults will take either caffeine or a placebo and perform tasks that test their ability to learn which choices lead to monetary rewards. The goal is to understand how caffeine affects the brain's reward system.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
caffeine
What this could lead to
If successful, this could help us understand how caffeine influences learning and habit formation.
What could go wrong
This is a small, early-stage study in healthy volunteers, so results may not apply to the general population or have immediate practical uses.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 36 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2022

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 and ≤ 40 * Clinically healthy * Non-smokers Exclusion Criteria: * Habitual caffeine intake \< 100 mg or \> 450 mg * Pregnant or lactating women * Women using hormonal contraceptives * BMI \< 18.5 or \> 29.9 * Sleep disturbance or extreme chronotypes * Nicotine or recreational drug users * Depression, anxiety, psychosis, or neurologic disorders * Severe heart or cardiovascular diseases * Diabetes or metabolic diseases * Under chronic medications * Incapable to operate the tasks or comprehend the study information in German or English * Users of the Bopomo alphates utilized as stimuli in the reward learning tasks * Current enrolment in other clinical trials

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Caffeine

Contacts and locations

Locations

  • Centre for Chronobiology, University Psychiatric Clinics Basel

    Basel, Canton of Basel-City, CH-4002, Switzerland

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