New drug shows promise in slowing advanced neuroendocrine tumors
NCT ID NCT03375320
First seen Jun 27, 2026 · Last updated Aug 05, 2026 · Updated 3 times
Summary
This study tests whether the drug cabozantinib can slow the growth of advanced neuroendocrine tumors (including carcinoid tumors) compared to a placebo. About 298 adults whose cancer worsened after prior treatment will receive either cabozantinib or a placebo pill. The main goal is to see how long the cancer stays under control.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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298 people
The number who actually took part.
- Started
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Oct 2018
- Expected to finish
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Aug 2026
An estimate. End dates often move.
- Lead sponsor
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A government research agency
The lead sponsor is the US National Institutes of Health.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Documentation of Disease: * Histologic Documentation: Well- or moderately-differentiated neuroendocrine tumors of pancreatic and non-pancreatic (i.e. carcinoid) origin by local pathology * The pathology report must state ONE of the following: 1) well- or moderately-differentiated neuroendocrine tumor, 2) low- or intermediate-grade neuroendocrine tumor, or 3) carcinoid tumor or atypical carcinoid tumor; documentation of histology from a primary or metastatic site is allowed * Patients with poorly differentiated neuroendocrine carcinoma, high-grade neuroendocrine carcinoma without specification of differentiation status, adenocarcinoid tumor, or goblet cell carcinoid tumor are not eligible. Patients with well-differentiated grade 3 neuroendocrine tumor are eligible * Stage: Locally advanced/unresectable or metastatic disease * Tumor Site: Histological documentation of neuroendocrine tumor of pancreatic, gastrointestinal (GI), lung, thymus, other, or unknown primary site; GI, lung, thymus, other, and unknown primary NETs will enroll in the carcinoid tumor cohort of the study * Functional (i.e., associated with symptoms or clinical syndrome related to hormone secretion by tumor) or nonfunctional tumors are allowed * Radiologic Evaluation: Target lesions must have shown evidence of disease progression by Response Evaluation Criteria in Solid Tumors (RECIST) version (v)1.1 criteria in the 12 months prior to registration; the radiologic images, imaging reports, and clinic notes indicating growth of existing lesions, development of new lesions, or treatment changes must be submitted * Measurable Disease * Patients must have measurable disease per RECIST 1.1 by computer tomography (CT) scan or magnetic resonance imaging (MRI) * Lesions must be accurately measured in at least one dimension (longest diameter to be recorded) as \>= 1 cm with CT or MRI (or \>= 1.5 cm for lymph nodes); non-measurable disease includes disease smaller than these dimensions or lesions considered truly non-measurable including: leptomeningeal disease, ascites, pleural or pericardial effusion, lymphangitic involvement of skin or lung * Prior Treatment * Patient must have experienced disease progression after receiving or intolerance leading to treatment discontinuation of at least one Food and Drug Administration (FDA)-approved line of therapy (except somatostatin analogs); prior lines of therapy must include one of the following: everolimus, sunitinib, or lutetium Lu 177 dotatate in patients with pancreatic NET; everolimus in patients with lung NET; everolimus or lutetium Lu 177 dotatate in patients with gastrointestinal NET * Prior treatment (except somatostatin analogs) with biologic therapy, immunotherapy, chemotherapy, investigational agent for malignancy, and/or radiation must be completed at least 28 days prior to registration * Prior treatment with somatostatin analogs is allowed, and continuation of treatment with somatostatin analogs while on cabozantinib/placebo is allowed provided that the patient has been on a stable dose for at least two months * Prior systemic treatment with radionuclide therapy must be completed at least 6 weeks prior to registration * Prior treatment with hepatic artery embolization (including bland embolization, chemoembolization, and selective internal radiation therapy) or ablative therapies is allowed if measurable disease remains outside of the treated area or if there is documented disease progression in a treated site; prior liver-directed or other ablative treatment must be completed at least 28 days prior to registration * Prior treatment with cabozantinib is not allowed * Patients should have resolution of any toxic effects of prior therapy (except alopecia and fatigue) to National Cancer Institute (NCI) CTCAE, version 5.0, grade 1 or less * Patients must have completed any major surgery at least 12 weeks prior to registration and any minor surgery (including uncomplicated tooth extractions) at least 28 days prior to registration; complete wound healing from major surgery must have occurred at least 28 days prior to registration, and complete wound healing from minor surgery must have occurred at least 10 days prior to registration * Patient History * No class III or IV congestive heart failure (CHF) within 6 months of registration * No clinically significant cardiac arrhythmia within 6 months of registration * No unstable angina or myocardial infarction (MI) within 6 months of registration * No thromboembolic events within 6 months of registration (including \[incl.\] stroke, transient ischemic attack \[TIA\], deep vein thrombosis \[DVT\], \& pulmonary embolism \[PE\]) * No known history of congenital long QT syndrome * No uncontrolled hypertension within 14 days of registration (defined as systolic blood pressure \[SBP\] \>= 150 mmHg and/or diastolic blood pressure \[DBP\] \>= 90 mmHg despite optimal medical management) * No clinically significant GI bleeding within 6 months of registration * No clinically significant gastrointestinal abnormalities that may increase the risk for gastrointestinal bleeding within 6 months of registration including, but not limited to: active peptic ulcer, known endoluminal metastatic lesion(s) with history of bleeding, inflammatory bowel disease, or other gastrointestinal conditions with increased risk of perforation * No GI perforation within 6 months of registration * No known tumor with invasion into the GI tract from the outside causing increased risk of perforation or bleeding within 28 days of registration * No radiologic or clinical evidence of pancreatitis * No known cavitary lung lesions * No known endobronchial lesions involving the main or lobar bronchi and/or lesions infiltrating major pulmonary vessels that increase the risk of pulmonary hemorrhage; (CT with contrast is recommended to evaluate such lesions) * No hemoptysis greater than 1/2 teaspoon (2.5 mL) or any other signs of pulmonary hemorrhage within the 3 months prior to registration * No known tumor invading or encasing any major blood vessels * No history of non-healing wounds or ulcers within 28 days of registration * No history of fracture within 28 days of registration * No brain metastases or cranial epidural disease unless adequately treated, stable, and off steroid support for at least 4 weeks prior to registration * No known medical condition causing an inability to swallow oral formulations of agents * No history of allergic reaction attributed to compounds of similar chemical or biological composition to cabozantinib/placebo * No "currently active" second malignancy other than non-melanoma skin cancers or cervical carcinoma in situ; patients are not considered to have a "currently active" malignancy if they have completed therapy and are free of disease for \>= 3 years * Concomitant Medications * Other planned concurrent investigational agents or other tumor directed therapies (chemotherapy, radiation) are not allowed while on this study * Concurrent use of somatostatin analogs while on cabozantinib/placebo is allowed provided that the patient has been on a stable dose for at least two months * Full dose oral anticoagulation/antiplatelet therapy is not permitted; low dose aspirin =\< 81 mg/day is allowed; anticoagulation with therapeutic doses of low molecular weight heparin (LMWH) is allowed in patients who are on a stable dose of LMWH for at least 6 weeks prior to registration; treatment with warfarin is not allowed; anticoagulation in patients with brain metastases is not permitted * Chronic concomitant treatment with strong inhibitors of CYP3A4 is not allowed; patients must discontinue the drug at least 14 days prior to registration on the study * Chronic concomitant treatment with strong CYP3A4 inducers is not allowed; patients must discontinue the drug at least 14 days prior to registration on the study * Not pregnant and not nursing * Women of childbearing potential must have a negative pregnancy test done =\< 14 days prior to registration * A female of childbearing potential is a sexually mature female who: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 12 consecutive months (i.e. has had menses at any time in the preceding 12 consecutive months) * Age \>= 18 years * Eastern Cooperative Oncology Group (ECOG) performance status: 0-2 * Absolute neutrophil count (ANC) \>= 1,500/mm\^3 * Hemoglobin \>= 9 g/dL * Platelet count \>= 100,000/mm\^3 * Prothrombin time (PT)/ international normalized ratio (INR), partial thromboplastin time (PTT) \< 1.3 x upper limit of normal (ULN) * Aspartate aminotransferase (AST)/ alanine aminotransferase (ALT) =\< 3 x ULN * Total bilirubin =\< 1.5 x ULN * Except in the case of Gilbert disease, in which case total bilirubin must be =\< 3 x ULN * Creatinine =\< 1.5 mg/dL OR creatinine clearance \>= 45 mL/min * Albumin \>= 2.8 g/dL * Potassium within normal limits (WNL) * Supplementation is acceptable to achieve a value WNL; in patients with low albumin levels, a corrected calcium value WNL is acceptable; in patients with abnormal thyroid stimulating hormone (TSH), if free T4 is normal and patient is clinically euthyroid, patient is eligible * Phosphorus WNL * Supplementation is acceptable to achieve a value WNL; in patients with low albumin levels, a corrected calcium value WNL is acceptable; in patients with abnormal TSH, if free T4 is normal and patient is clinically euthyroid, patient is eligible * Calcium WNL * Supplementation is acceptable to achieve a value WNL; in patients with low albumin levels, a corrected calcium value WNL is acceptable; in patients with abnormal TSH, if free T4 is normal and patient is clinically euthyroid, patient is eligible * Magnesium WNL * Supplementation is acceptable to achieve a value WNL; in patients with low albumin levels, a corrected calcium value WNL is acceptable; in patients with abnormal TSH, if free T4 is normal and patient is clinically euthyroid, patient is eligible * Urine protein to creatinine (UPC) ratio =\< 1 * QT interval corrected for heart rate using Fridericia's formula (QTcF) =\< 500 msec * TSH WNL * Supplementation is acceptable to achieve a value WNL; in patients with low albumin levels, a corrected calcium value WNL is acceptable; in patients with abnormal TSH, if free T4 is normal and patient is clinically euthyroid, patient is eligible
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Abbott-Northwestern Hospital
Minneapolis, Minnesota, 55407, United States
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Adena Regional Medical Center
Chillicothe, Ohio, 45601, United States
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Advanced Breast Care Center PLLC
Warren, Michigan, 48088, United States
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Allegheny General Hospital
Pittsburgh, Pennsylvania, 15212, United States
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Alta Bates Summit Medical Center - Summit Campus
Oakland, California, 94609, United States
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Alta Bates Summit Medical Center-Herrick Campus
Berkeley, California, 94704, United States
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Ann M Wierman MD LTD
Las Vegas, Nevada, 89128, United States
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Atrium Medical Center-Middletown Regional Hospital
Franklin, Ohio, 45005-1066, United States
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Banner North Colorado Medical Center
Greeley, Colorado, 80631, United States
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Banner North Colorado Medical Center - Loveland Campus
Loveland, Colorado, 80539, United States
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Banner University Medical Center - Tucson
Tucson, Arizona, 85719, United States
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Beacon Kalamazoo Cancer Center
Kalamazoo, Michigan, 49009, United States
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Benefis Sletten Cancer Institute
Great Falls, Montana, 59405, United States
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Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215, United States
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Bhadresh Nayak MD PC-Sterling Heights
Sterling Heights, Michigan, 48312, United States
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Billings Clinic Cancer Center
Billings, Montana, 59101, United States
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Billings Clinic-Cody
Cody, Wyoming, 82414, United States
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Boston Medical Center
Boston, Massachusetts, 02118, United States
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Bozeman Health Deaconess Hospital
Bozeman, Montana, 59715, United States
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Brigham and Women's Hospital
Boston, Massachusetts, 02115, United States
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Broadlawns Medical Center
Des Moines, Iowa, 50314, United States
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Bronson Battle Creek
Battle Creek, Michigan, 49017, United States
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Bronson Methodist Hospital
Kalamazoo, Michigan, 49007, United States
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California Pacific Medical Center-Pacific Campus
San Francisco, California, 94115, United States
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Cancer Care Center of O'Fallon
O'Fallon, Illinois, 62269, United States
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Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois, 62526, United States
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Cancer Center of Western Wisconsin
New Richmond, Wisconsin, 54017, United States
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Cancer Hematology Centers - Flint
Flint, Michigan, 48503, United States
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Cancer Therapy and Integrative Medicine
Las Vegas, Nevada, 89121, United States
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Cancer and Blood Specialists-Henderson
Henderson, Nevada, 89052, United States
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Cancer and Blood Specialists-Shadow
Las Vegas, Nevada, 89106, United States
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Cancer and Blood Specialists-Tenaya
Las Vegas, Nevada, 89128, United States
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Carle Cancer Center
Urbana, Illinois, 61801, United States
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Carle Physician Group-Effingham
Effingham, Illinois, 62401, United States
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Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois, 61938, United States
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Carle at The Riverfront
Danville, Illinois, 61832, United States
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Caro Cancer Center
Caro, Michigan, 48723, United States
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Carson Tahoe Regional Medical Center
Carson City, Nevada, 89703, United States
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Case Western Reserve University
Cleveland, Ohio, 44106, United States
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Chelsea Hospital
Chelsea, Michigan, 48118, United States
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City of Hope Comprehensive Cancer Center
Duarte, California, 91010, United States
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Columbus Oncology and Hematology Associates Inc
Columbus, Ohio, 43214, United States
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Community Hospital of Anaconda
Anaconda, Montana, 59711, United States
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Community Medical Center
Missoula, Montana, 59804, United States
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Comprehensive Cancer Centers of Nevada
Las Vegas, Nevada, 89148, United States
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Comprehensive Cancer Centers of Nevada - Central Valley
Las Vegas, Nevada, 89169, United States
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Comprehensive Cancer Centers of Nevada - Henderson
Henderson, Nevada, 89052, United States
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Comprehensive Cancer Centers of Nevada - Northwest
Las Vegas, Nevada, 89128, United States
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Comprehensive Cancer Centers of Nevada-Horizon Ridge
Henderson, Nevada, 89052, United States
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Comprehensive Cancer Centers of Nevada-Southeast Henderson
Henderson, Nevada, 89074, United States
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Comprehensive Cancer Centers of Nevada-Summerlin
Las Vegas, Nevada, 89144, United States
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Contra Costa Regional Medical Center
Martinez, California, 94553-3156, United States
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Crossroads Cancer Center
Effingham, Illinois, 62401, United States
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Danbury Hospital
Danbury, Connecticut, 06810, United States
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Dartmouth Cancer Center - Nashua
Nashua, New Hampshire, 03063, United States
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Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon, New Hampshire, 03756, United States
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Delaware Health Center-Grady Cancer Center
Delaware, Ohio, 43015, United States
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Desert West Surgery
Las Vegas, Nevada, 89102, United States
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Doctors Hospital
Columbus, Ohio, 43228, United States
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Duluth Clinic Ashland
Ashland, Wisconsin, 54806, United States
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ECU Health Oncology Kinston
Kinston, North Carolina, 28501, United States
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Edwards Comprehensive Cancer Center
Huntington, West Virginia, 25701, United States
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Emory Saint Joseph's Hospital
Atlanta, Georgia, 30342, United States
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Emory University Hospital Midtown
Atlanta, Georgia, 30308, United States
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Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia, 30322, United States
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Englewood Hospital and Medical Center
Englewood, New Jersey, 07631, United States
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Epic Care Partners in Cancer Care
Emeryville, California, 94608, United States
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Epic Care-Dublin
Dublin, California, 94568, United States
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Essentia Health - Deer River Clinic
Deer River, Minnesota, 56636, United States
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Essentia Health Cancer Center
Duluth, Minnesota, 55805, United States
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Essentia Health Hibbing Clinic
Hibbing, Minnesota, 55746, United States
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Essentia Health Sandstone
Sandstone, Minnesota, 55072, United States
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Essentia Health Virginia Clinic
Virginia, Minnesota, 55792, United States
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Fairview Clinics and Surgery Center Maple Grove
Maple Grove, Minnesota, 55369, United States
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Fairview Lakes Medical Center
Wyoming, Minnesota, 55092, United States
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Fairview Ridges Hospital
Burnsville, Minnesota, 55337, United States
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Fairview Southdale Hospital
Edina, Minnesota, 55435, United States
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Farmington Health Center
Farmington, Utah, 84025, United States
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Forbes Hospital
Monroeville, Pennsylvania, 15146, United States
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Fox Chase Cancer Center
Philadelphia, Pennsylvania, 19111, United States
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Fremont - Rideout Cancer Center
Marysville, California, 95901, United States
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Genesee Hematology Oncology PC
Flint, Michigan, 48503, United States
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Genesis Healthcare System Cancer Care Center
Zanesville, Ohio, 43701, United States
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GenesisCare USA - Aventura
Aventura, Florida, 33180, United States
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GenesisCare USA - Aventura FP
Aventura, Florida, 33180, United States
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GenesisCare USA - Boca Ration FP06
Boca Raton, Florida, 33431, United States
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Genesys Hurley Cancer Institute
Flint, Michigan, 48503, United States
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Good Samaritan Hospital - Cancer Centers of Colorado
Lafayette, Colorado, 80026, United States
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Grant Medical Center
Columbus, Ohio, 43215, United States
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Great Falls Clinic
Great Falls, Montana, 59405, United States
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Greater Regional Medical Center
Creston, Iowa, 50801, United States
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Hawaii Cancer Care - Westridge
‘Aiea, Hawaii, 96701, United States
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Hawaii Cancer Care Inc - Waterfront Plaza
Honolulu, Hawaii, 96813, United States
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Health Partners Inc
Minneapolis, Minnesota, 55454, United States
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HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
Las Vegas, Nevada, 89149, United States
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HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
Las Vegas, Nevada, 89109, United States
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HealthCare Partners Medical Group Oncology/Hematology-San Martin
Las Vegas, Nevada, 89113, United States
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HealthCare Partners Medical Group Oncology/Hematology-Tenaya
Las Vegas, Nevada, 89128, United States
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Heartland Oncology and Hematology LLP
Council Bluffs, Iowa, 51503, United States
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Hematology Oncology Associates of CNY at Camillus
Camillus, New York, 13031, United States
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Hematology Oncology Associates of Central New York-Auburn
Auburn, New York, 13021, United States
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Hematology Oncology Associates of Central New York-East Syracuse
East Syracuse, New York, 13057, United States
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Hematology Oncology Consultants-Clarkston
Clarkston, Michigan, 48346, United States
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Hennepin County Medical Center
Minneapolis, Minnesota, 55415, United States
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Henry Ford Health Saint John Hospital
Detroit, Michigan, 48236, United States
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Henry Ford Health Warren Hospital
Warren, Michigan, 48093, United States
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Henry Ford Hospital
Detroit, Michigan, 48202, United States
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Henry Ford Madison Heights Hospital - Breast
Warren, Michigan, 48093, United States
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Henry Ford River District Hospital
East China Township, Michigan, 48054, United States
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Henry Ford Rochester Hospital
Rochester Hills, Michigan, 48309, United States
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Henry Ford Saint John Hospital - Academic
Grosse Pointe Woods, Michigan, 48236, United States
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Henry Ford Saint John Hospital - Breast
Grosse Pointe Woods, Michigan, 48236, United States
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Henry Ford Saint John Hospital - Macomb Medical
Macomb, Michigan, 48044, United States
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Henry Ford Saint John Hospital - Van Elslander
Grosse Pointe Woods, Michigan, 48236, United States
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Henry Ford Warren Hospital - Breast Macomb
Macomb, Michigan, 48044, United States
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Henry Ford Warren Hospital - GLCMS
Warren, Michigan, 48093, United States
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Hickman Cancer Center
Adrian, Michigan, 49221, United States
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Hope Cancer Care of Nevada
Las Vegas, Nevada, 89103, United States
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Hope Cancer Care of Nevada-Pahrump
Pahrump, Nevada, 89048, United States
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Hope Cancer Center
Pontiac, Michigan, 48341, United States
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Hope Cancer Clinic
Livonia, Michigan, 48154, United States
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Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah, 84112, United States
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Hurley Medical Center
Flint, Michigan, 48503, United States
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Huron Gastroenterology PC
Ypsilanti, Michigan, 48106, United States
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Huron Medical Center PC
Port Huron, Michigan, 48060, United States
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Idaho Urologic Institute-Meridian
Meridian, Idaho, 83642, United States
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Illinois CancerCare - Washington
Washington, Illinois, 61571, United States
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Illinois CancerCare-Bloomington
Bloomington, Illinois, 61704, United States
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Illinois CancerCare-Canton
Canton, Illinois, 61520, United States
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Illinois CancerCare-Carthage
Carthage, Illinois, 62321, United States
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Illinois CancerCare-Dixon
Dixon, Illinois, 61021, United States
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Illinois CancerCare-Eureka
Eureka, Illinois, 61530, United States
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Illinois CancerCare-Galesburg
Galesburg, Illinois, 61401, United States
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Illinois CancerCare-Kewanee Clinic
Kewanee, Illinois, 61443, United States
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Illinois CancerCare-Macomb
Macomb, Illinois, 61455, United States
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Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois, 61350, United States
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Illinois CancerCare-Pekin
Pekin, Illinois, 61554, United States
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Illinois CancerCare-Peoria
Peoria, Illinois, 61615, United States
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Illinois CancerCare-Peru
Peru, Illinois, 61354, United States
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Illinois CancerCare-Princeton
Princeton, Illinois, 61356, United States
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Intermountain Health Lutheran Hospital
Wheat Ridge, Colorado, 80401, United States
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Iowa Methodist Medical Center
Des Moines, Iowa, 50309, United States
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Jefferson Hospital
Jefferson Hills, Pennsylvania, 15025, United States
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Kaiser Permanente Downtown Commons
Sacramento, California, 95814, United States
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Kaiser Permanente Medical Center - Santa Clara
Santa Clara, California, 95051, United States
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Kaiser Permanente Medical Center-Vacaville
Vacaville, California, 95688, United States
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Kaiser Permanente Moanalua Medical Center
Honolulu, Hawaii, 96819, United States
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Kaiser Permanente San Leandro
San Leandro, California, 94577, United States
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Kaiser Permanente-Deer Valley Medical Center
Antioch, California, 94531, United States
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Kaiser Permanente-Fremont
Fremont, California, 94538, United States
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Kaiser Permanente-Fresno
Fresno, California, 93720, United States
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Kaiser Permanente-Modesto
Modesto, California, 95356, United States
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Kaiser Permanente-Oakland
Oakland, California, 94611, United States
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Kaiser Permanente-Redwood City
Redwood City, California, 94063, United States
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Kaiser Permanente-Richmond
Richmond, California, 94801, United States
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Kaiser Permanente-Roseville
Roseville, California, 95661, United States
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Kaiser Permanente-San Francisco
San Francisco, California, 94115, United States
-
Kaiser Permanente-San Rafael
San Rafael, California, 94903, United States
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Kaiser Permanente-Santa Rosa
Santa Rosa, California, 95403, United States
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Kaiser Permanente-Santa Teresa-San Jose
San Jose, California, 95119, United States
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Kaiser Permanente-South Sacramento
Sacramento, California, 95823, United States
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Kaiser Permanente-South San Francisco
South San Francisco, California, 94080, United States
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Kaiser Permanente-Stockton
Stockton, California, 95210, United States
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Kaiser Permanente-Vallejo
Vallejo, California, 94589, United States
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Kaiser Permanente-Walnut Creek
Walnut Creek, California, 94596, United States
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Kaiser San Rafael-Gallinas
San Rafael, California, 94903, United States
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Karmanos Cancer Institute at McLaren Greater Lansing
Lansing, Michigan, 48910, United States
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Katmai Oncology Group
Anchorage, Alaska, 99508, United States
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Kingman Regional Medical Center
Kingman, Arizona, 86401, United States
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Kootenai Clinic Cancer Services - Post Falls
Post Falls, Idaho, 83854, United States
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Kootenai Clinic Cancer Services - Sandpoint
Sandpoint, Idaho, 83864, United States
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Kootenai Health - Coeur d'Alene
Coeur d'Alene, Idaho, 83814, United States
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LSU Health Baton Rouge-North Clinic
Baton Rouge, Louisiana, 70805, United States
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Lahey Clinic
Burlington, Massachusetts, 01805, United States
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Lake Huron Medical Center
Port Huron, Michigan, 48060, United States
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Lakeview Hospital
Stillwater, Minnesota, 55082, United States
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Las Vegas Cancer Center-Henderson
Henderson, Nevada, 89052, United States
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Las Vegas Cancer Center-Medical Center
Las Vegas, Nevada, 89148-2405, United States
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Lehigh Valley Hospital - Muhlenberg
Bethlehem, Pennsylvania, 18017, United States
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Lehigh Valley Hospital-Cedar Crest
Allentown, Pennsylvania, 18103, United States
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Lehigh Valley Hospital-Hazleton
Hazleton, Pennsylvania, 18201, United States
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Licking Memorial Hospital
Newark, Ohio, 43055, United States
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Logan Health Medical Center
Kalispell, Montana, 59901, United States
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Louisiana Hematology Oncology Associates LLC
Baton Rouge, Louisiana, 70809, United States
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Loyola University Medical Center
Maywood, Illinois, 60153, United States
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Macomb Hematology Oncology PC
Warren, Michigan, 48093, United States
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Margaret R Pardee Memorial Hospital
Hendersonville, North Carolina, 28791, United States
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Marietta Memorial Hospital
Marietta, Ohio, 45750, United States
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Marion L Shepard Cancer Center - ECU Health Beaufort Hospital
Washington, North Carolina, 27889, United States
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Marshfield Medical Center - Minocqua
Minocqua, Wisconsin, 54548, United States
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Marshfield Medical Center - Weston
Weston, Wisconsin, 54476, United States
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Marshfield Medical Center-EC Cancer Center
Eau Claire, Wisconsin, 54701, United States
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Marshfield Medical Center-Marshfield
Marshfield, Wisconsin, 54449, United States
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Marshfield Medical Center-Rice Lake
Rice Lake, Wisconsin, 54868, United States
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Marshfield Medical Center-River Region at Stevens Point
Stevens Point, Wisconsin, 54482, United States
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Mary Bird Perkins Cancer Center
Baton Rouge, Louisiana, 70809, United States
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Mayo Clinic Hospital in Arizona
Phoenix, Arizona, 85054, United States
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Mayo Clinic in Florida
Jacksonville, Florida, 32224-9980, United States
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Mayo Clinic in Rochester
Rochester, Minnesota, 55905, United States
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McLaren Cancer Institute-Central Michigan
Mount Pleasant, Michigan, 48858, United States
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McLaren Cancer Institute-Clarkston
Clarkston, Michigan, 48346, United States
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McLaren Cancer Institute-Flint
Flint, Michigan, 48532, United States
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McLaren Cancer Institute-Macomb
Mount Clemens, Michigan, 48043, United States
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McLaren Cancer Institute-Northern Michigan
Petoskey, Michigan, 49770, United States
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McLaren-Port Huron
Port Huron, Michigan, 48060, United States
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MedStar Georgetown University Hospital
Washington D.C., District of Columbia, 20007, United States
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Memorial Hospital of South Bend
South Bend, Indiana, 46601, United States
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Memorial Medical Center
Modesto, California, 95355, United States
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Memorial Regional Hospital/Joe DiMaggio Children's Hospital
Hollywood, Florida, 33021, United States
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Memorial Sloan Kettering Basking Ridge
Basking Ridge, New Jersey, 07920, United States
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Memorial Sloan Kettering Bergen
Montvale, New Jersey, 07645, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Memorial Sloan Kettering Commack
Commack, New York, 11725, United States
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Memorial Sloan Kettering Monmouth
Middletown, New Jersey, 07748, United States
-
Memorial Sloan Kettering Nassau
Uniondale, New York, 11553, United States
-
Memorial Sloan Kettering Westchester
Harrison, New York, 10604, United States
-
Mercy Cancer Center-West Lakes
Clive, Iowa, 50325, United States
-
Mercy Health - Perrysburg Hospital
Perrysburg, Ohio, 43551, United States
-
Mercy Health - Saint Anne Hospital
Toledo, Ohio, 43623, United States
-
Mercy Hospital
Cedar Rapids, Iowa, 52403, United States
-
Mercy Hospital
Coon Rapids, Minnesota, 55433, United States
-
Mercy Medical Center - Des Moines
Des Moines, Iowa, 50314, United States
-
Mercy Medical Center-West Lakes
West Des Moines, Iowa, 50266, United States
-
Methodist Jennie Edmundson Hospital
Council Bluffs, Iowa, 51503, United States
-
Miami Valley Hospital
Dayton, Ohio, 45409, United States
-
Miami Valley Hospital North
Dayton, Ohio, 45415, United States
-
Miami Valley Hospital South
Centerville, Ohio, 45459, United States
-
Michigan Healthcare Professionals Pontiac
Pontiac, Michigan, 48341, United States
-
Mills Health Center
San Mateo, California, 94401, United States
-
Mills-Peninsula Medical Center
Burlingame, California, 94010, United States
-
Minnesota Oncology - Burnsville
Burnsville, Minnesota, 55337, United States
-
Minnesota Oncology Hematology PA-Maplewood
Maplewood, Minnesota, 55109, United States
-
Minnesota Oncology Hematology PA-Woodbury
Woodbury, Minnesota, 55125, United States
-
Missouri Baptist Medical Center
St Louis, Missouri, 63131, United States
-
Missouri Baptist Sullivan Hospital
Sullivan, Missouri, 63080, United States
-
Moffitt Cancer Center
Tampa, Florida, 33612, United States
-
Mount Sinai Hospital
New York, New York, 10029, United States
-
Mountain Blue Cancer Care Center - Swedish
Englewood, Colorado, 80113, United States
-
MyMichigan Medical Center Saginaw
Saginaw, Michigan, 48601, United States
-
MyMichigan Medical Center Tawas
Tawas City, Michigan, 48764, United States
-
National Jewish Health-Main Campus
Denver, Colorado, 80206, United States
-
National Jewish Health-Northern Hematology Oncology
Thornton, Colorado, 80260, United States
-
National Jewish Health-Western Hematology Oncology
Golden, Colorado, 80401, United States
-
Nebraska Cancer Specialists/Oncology Hematology West PC
Grand Island, Nebraska, 68803, United States
-
Nebraska Cancer Specialists/Oncology Hematology West PC - MECC
Omaha, Nebraska, 68114, United States
-
Nebraska Methodist Hospital
Omaha, Nebraska, 68114, United States
-
New Mexico Oncology Hematology Consultants
Albuquerque, New Mexico, 87109, United States
-
New Ulm Medical Center
New Ulm, Minnesota, 56073, United States
-
Newland Medical Associates-Clarkston
Clarkston, Michigan, 48346, United States
-
Newland Medical Associates-Pontiac
Pontiac, Michigan, 48341, United States
-
North Memorial Medical Health Center
Robbinsdale, Minnesota, 55422, United States
-
Northshore Oncology Associates-Covington
Covington, Louisiana, 70433, United States
-
Norwalk Hospital
Norwalk, Connecticut, 06856, United States
-
Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210, United States
-
OhioHealth Mansfield Hospital
Mansfield, Ohio, 44903, United States
-
OhioHealth Marion General Hospital
Marion, Ohio, 43302, United States
-
Oklahoma Cancer Specialists and Research Institute-Tulsa
Tulsa, Oklahoma, 74146, United States
-
Oncology Associates PC
Omaha, Nebraska, 68114, United States
-
Oncology Associates at Mercy Medical Center
Cedar Rapids, Iowa, 52403, United States
-
Oncology Center of The South Incorporated
Houma, Louisiana, 70360, United States
-
Oncology Hematology Associates of Saginaw Valley PC
Saginaw, Michigan, 48604, United States
-
Oncology Las Vegas - Henderson
Henderson, Nevada, 89074, United States
-
Oncology Las Vegas - Tenaya
Las Vegas, Nevada, 89128, United States
-
OptumCare Cancer Care at Charleston
Las Vegas, Nevada, 89102, United States
-
OptumCare Cancer Care at Fort Apache
Las Vegas, Nevada, 89183, United States
-
OptumCare Cancer Care at MountainView
Las Vegas, Nevada, 89128, United States
-
Our Lady of The Lake
Baton Rouge, Louisiana, 70808, United States
-
Our Lady of the Lake Physician Group
Baton Rouge, Louisiana, 70808, United States
-
PCR Oncology
Arroyo Grande, California, 93420, United States
-
Pali Momi Medical Center
‘Aiea, Hawaii, 96701, United States
-
Palo Alto Medical Foundation Health Care
Palo Alto, California, 94301, United States
-
Palo Alto Medical Foundation-Camino Division
Mountain View, California, 94040, United States
-
Palo Alto Medical Foundation-Fremont
Fremont, California, 94538, United States
-
Palo Alto Medical Foundation-Santa Cruz
Santa Cruz, California, 95065, United States
-
Palo Alto Medical Foundation-Sunnyvale
Sunnyvale, California, 94086, United States
-
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, Minnesota, 55416, United States
-
Parkland Health Center - Farmington
Farmington, Missouri, 63640, United States
-
Parkland Health Center-Bonne Terre
Bonne Terre, Missouri, 63628, United States
-
Penrose-Saint Francis Healthcare
Colorado Springs, Colorado, 80907, United States
-
Pocono Medical Center
East Stroudsburg, Pennsylvania, 18301, United States
-
Premier Blood and Cancer Center
Dayton, Ohio, 45409, United States
-
Presbyterian Kaseman Hospital
Albuquerque, New Mexico, 87110, United States
-
Presbyterian Rust Medical Center/Jorgensen Cancer Center
Rio Rancho, New Mexico, 87124, United States
-
Prisma Health Cancer Institute - Butternut
Greenville, South Carolina, 29605, United States
-
Prisma Health Cancer Institute - Easley
Easley, South Carolina, 29640, United States
-
Prisma Health Cancer Institute - Eastside
Greenville, South Carolina, 29615, United States
-
Prisma Health Cancer Institute - Faris
Greenville, South Carolina, 29605, United States
-
Prisma Health Cancer Institute - Greer
Greer, South Carolina, 29650, United States
-
Prisma Health Cancer Institute - Seneca
Seneca, South Carolina, 29672, United States
-
Prisma Health Cancer Institute - Spartanburg
Boiling Springs, South Carolina, 29316, United States
-
ProHealth D N Greenwald Center
Mukwonago, Wisconsin, 53149, United States
-
ProHealth Oconomowoc Memorial Hospital
Oconomowoc, Wisconsin, 53066, United States
-
ProHealth Waukesha Memorial Hospital
Waukesha, Wisconsin, 53188, United States
-
Providence Cancer Institute Clackamas Clinic
Clackamas, Oregon, 97015, United States
-
Providence Newberg Medical Center
Newberg, Oregon, 97132, United States
-
Providence Portland Medical Center
Portland, Oregon, 97213, United States
-
Providence Saint Vincent Medical Center
Portland, Oregon, 97225, United States
-
Queen's Cancer Cenrer - POB I
Honolulu, Hawaii, 96813, United States
-
Queen's Cancer Center - Kuakini
Honolulu, Hawaii, 96817, United States
-
Queen's Medical Center
Honolulu, Hawaii, 96813, United States
-
Radiation Oncology Associates
Reno, Nevada, 89509, United States
-
Radiation Oncology Centers of Nevada Central
Las Vegas, Nevada, 89106, United States
-
Radiation Oncology Centers of Nevada Southeast
Las Vegas, Nevada, 89119, United States
-
Regional Cancer Center-Lee Memorial Health System
Fort Myers, Florida, 33905, United States
-
Regions Hospital
Saint Paul, Minnesota, 55101, United States
-
Renown Regional Medical Center
Reno, Nevada, 89502, United States
-
Rice Memorial Hospital
Willmar, Minnesota, 56201, United States
-
Ridgeview Medical Center
Waconia, Minnesota, 55387, United States
-
Rocky Mountain Cancer Centers-Aurora
Aurora, Colorado, 80012, United States
-
Rocky Mountain Cancer Centers-Boulder
Boulder, Colorado, 80304, United States
-
Rocky Mountain Cancer Centers-Littleton
Littleton, Colorado, 80120, United States
-
Rocky Mountain Cancer Centers-Midtown
Denver, Colorado, 80218, United States
-
Rocky Mountain Cancer Centers-Rose
Denver, Colorado, 80220, United States
-
Rocky Mountain Cancer Centers-Sky Ridge
Lone Tree, Colorado, 80124, United States
-
Roswell Park Cancer Institute
Buffalo, New York, 14263, United States
-
Saint Alphonsus Cancer Care Center-Baker City
Baker City, Oregon, 97814, United States
-
Saint Alphonsus Cancer Care Center-Boise
Boise, Idaho, 83706, United States
-
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell, Idaho, 83605, United States
-
Saint Alphonsus Cancer Care Center-Nampa
Nampa, Idaho, 83687, United States
-
Saint Alphonsus Cancer Care Center-Ontario
Ontario, Oregon, 97914, United States
-
Saint Francis Medical Center
Cape Girardeau, Missouri, 63703, United States
-
Saint Francis Regional Medical Center
Shakopee, Minnesota, 55379, United States
-
Saint James Community Hospital and Cancer Treatment Center
Butte, Montana, 59701, United States
-
Saint John's Hospital - Healtheast
Maplewood, Minnesota, 55109, United States
-
Saint Joseph Hospital - Cancer Centers of Colorado
Denver, Colorado, 80218, United States
-
Saint Luke's Cancer Institute - Boise
Boise, Idaho, 83712, United States
-
Saint Luke's Cancer Institute - Fruitland
Fruitland, Idaho, 83619, United States
-
Saint Luke's Cancer Institute - Meridian
Meridian, Idaho, 83642, United States
-
Saint Luke's Cancer Institute - Nampa
Nampa, Idaho, 83687, United States
-
Saint Luke's Cancer Institute - Twin Falls
Twin Falls, Idaho, 83301, United States
-
Saint Mary's Hospital and Regional Medical Center
Grand Junction, Colorado, 81501, United States
-
Saint Mary's Oncology/Hematology Associates of Marlette
Marlette, Michigan, 48453, United States
-
Saint Mary's Oncology/Hematology Associates of West Branch
West Branch, Michigan, 48661, United States
-
Saint Mary's Regional Medical Center
Reno, Nevada, 89503, United States
-
Saint Peter's Community Hospital
Helena, Montana, 59601, United States
-
Saint Vincent Frontier Cancer Center
Billings, Montana, 59102, United States
-
Saint Vincent Hospital
Erie, Pennsylvania, 16544, United States
-
Sainte Genevieve County Memorial Hospital
Sainte Genevieve, Missouri, 63670, United States
-
Salinas Valley Memorial
Salinas, California, 93901, United States
-
Sanford Bismarck Medical Center
Bismarck, North Dakota, 58501, United States
-
Sanford Broadway Medical Center
Fargo, North Dakota, 58122, United States
-
Sanford Cancer Center Oncology Clinic
Sioux Falls, South Dakota, 57104, United States
-
Sanford Joe Lueken Cancer Center
Bemidji, Minnesota, 56601, United States
-
Sanford Roger Maris Cancer Center
Fargo, North Dakota, 58122, United States
-
Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota, 57117-5134, United States
-
Singh and Arora Hematology Oncology PC
Flint, Michigan, 48532, United States
-
Siteman Cancer Center at Christian Hospital
St Louis, Missouri, 63136, United States
-
Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters, Missouri, 63376, United States
-
Siteman Cancer Center at West County Hospital
Creve Coeur, Missouri, 63141, United States
-
Siteman Cancer Center-South County
St Louis, Missouri, 63129, United States
-
Southeastern Medical Oncology Center-Clinton
Clinton, North Carolina, 28328, United States
-
Southeastern Medical Oncology Center-Goldsboro
Goldsboro, North Carolina, 27534, United States
-
Southeastern Medical Oncology Center-Jacksonville
Jacksonville, North Carolina, 28546, United States
-
Southern Illinois University School of Medicine
Springfield, Illinois, 62702, United States
-
Southern Ohio Medical Center
Portsmouth, Ohio, 45662, United States
-
Springfield Clinic
Springfield, Illinois, 62702, United States
-
Stanford Cancer Institute Palo Alto
Palo Alto, California, 94304, United States
-
Straub Clinic and Hospital
Honolulu, Hawaii, 96813, United States
-
Strecker Cancer Center-Belpre
Belpre, Ohio, 45714, United States
-
Summerlin Hospital Medical Center
Las Vegas, Nevada, 89144, United States
-
Sutter Auburn Faith Hospital
Auburn, California, 95602, United States
-
Sutter Medical Center Sacramento
Sacramento, California, 95816, United States
-
Sutter Roseville Medical Center
Roseville, California, 95661, United States
-
Sutter Solano Medical Center/Cancer Center
Vallejo, California, 94589, United States
-
Swedish Medical Center
Englewood, Colorado, 80113, United States
-
Temple University Hospital
Philadelphia, Pennsylvania, 19140, United States
-
The Mark H Zangmeister Center
Columbus, Ohio, 43219, United States
-
The Valley Hospital - Luckow Pavilion
Paramus, New Jersey, 07652, United States
-
ThedaCare Regional Cancer Center
Appleton, Wisconsin, 54911, United States
-
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, 19107, United States
-
Toledo Clinic Cancer Centers-Maumee
Maumee, Ohio, 43537, United States
-
Toledo Clinic Cancer Centers-Monroe
Monroe, Michigan, 48162, United States
-
Toledo Clinic Cancer Centers-Toledo
Toledo, Ohio, 43623, United States
-
Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
Maumee, Ohio, 43537, United States
-
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton, Michigan, 48114, United States
-
Trinity Health IHA Medical Group Hematology Oncology - Canton
Canton, Michigan, 48188, United States
-
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea, Michigan, 48118, United States
-
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti, Michigan, 48197, United States
-
Trinity Health Medical Center - Brighton
Brighton, Michigan, 48114, United States
-
Trinity Health Medical Center - Canton
Canton, Michigan, 48188, United States
-
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor, Michigan, 48106, United States
-
Trinity Health Saint Joseph Mercy Oakland Hospital
Pontiac, Michigan, 48341, United States
-
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, Michigan, 48154, United States
-
UC Comprehensive Cancer Center at Silver Cross
New Lenox, Illinois, 60451, United States
-
UCSF Medical Center-Mission Bay
San Francisco, California, 94158, United States
-
UH Seidman Cancer Center at Lake Health Mentor Campus
Mentor, Ohio, 44060, United States
-
UH Seidman Cancer Center at Saint John Medical Center
Westlake, Ohio, 44145, United States
-
UH Seidman Cancer Center at Southwest General Hospital
Middleburg Heights, Ohio, 44130, United States
-
UHHS-Chagrin Highlands Medical Center
Beachwood, Ohio, 44122, United States
-
UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines, Iowa, 50309, United States
-
UI Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines, Iowa, 50314, United States
-
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
Clive, Iowa, 50325, United States
-
UI Healthcare Mission Cancer and Blood - Fort Dodge
Fort Dodge, Iowa, 50501, United States
-
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina, 27599, United States
-
UW Cancer Center at ProHealth Care
Waukesha, Wisconsin, 53188, United States
-
United Hospital
Saint Paul, Minnesota, 55102, United States
-
Unity Hospital
Fridley, Minnesota, 55432, United States
-
University Cancer Center
Las Vegas, Nevada, 89169, United States
-
University Hospitals Parma Medical Center
Parma, Ohio, 44129, United States
-
University Hospitals Sharon Health Center
Wadsworth, Ohio, 44281, United States
-
University Medical Center of Southern Nevada
Las Vegas, Nevada, 89102, United States
-
University of Arizona Cancer Center-North Campus
Tucson, Arizona, 85719, United States
-
University of Arkansas for Medical Sciences
Little Rock, Arkansas, 72205, United States
-
University of California Davis Comprehensive Cancer Center
Sacramento, California, 95817, United States
-
University of Chicago Comprehensive Cancer Center
Chicago, Illinois, 60637, United States
-
University of Chicago Medicine-Orland Park
Orland Park, Illinois, 60462, United States
-
University of Illinois
Chicago, Illinois, 60612, United States
-
University of Iowa Healthcare Cancer Services Quad Cities
Bettendorf, Iowa, 52722, United States
-
University of Iowa/Holden Comprehensive Cancer Center
Iowa City, Iowa, 52242, United States
-
University of Kentucky/Markey Cancer Center
Lexington, Kentucky, 40536, United States
-
University of Michigan Health - Sparrow Lansing
Lansing, Michigan, 48912, United States
-
University of Michigan Rogel Cancer Center
Ann Arbor, Michigan, 48109, United States
-
University of New Mexico Cancer Center
Albuquerque, New Mexico, 87106, United States
-
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73104, United States
-
University of Rochester
Rochester, New York, 14642, United States
-
University of Utah Sugarhouse Health Center
Salt Lake City, Utah, 84106, United States
-
University of Wisconsin Carbone Cancer Center - University Hospital
Madison, Wisconsin, 53792, United States
-
Upper Valley Medical Center
Troy, Ohio, 45373, United States
-
Valley Health System Ridgewood Campus
Ridgewood, New Jersey, 07450, United States
-
Valley Medical Group - Wayne Multispecialty Practice
Wayne, New Jersey, 07470, United States
-
Virginia Mason Medical Center
Seattle, Washington, 98101, United States
-
Walter Knox Memorial Hospital
Emmett, Idaho, 83617, United States
-
Washington University School of Medicine
St Louis, Missouri, 63110, United States
-
Wayne State University/Karmanos Cancer Institute
Detroit, Michigan, 48201, United States
-
Weisberg Cancer Treatment Center
Farmington Hills, Michigan, 48334, United States
-
Welch Cancer Center
Sheridan, Wyoming, 82801, United States
-
West Michigan Cancer Center
Kalamazoo, Michigan, 49007, United States
-
West Penn Hospital
Pittsburgh, Pennsylvania, 15224, United States
-
West Virginia University Healthcare
Morgantown, West Virginia, 26506, United States
-
Wexford Health and Wellness Pavilion
Wexford, Pennsylvania, 15090, United States
-
Wilmot Cancer Institute at Webster
Webster, New York, 14580, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Tiny DNA fragments in blood could reveal how aggressive a pancreatic tumor will be
- Swiss registry aims to map rare neuroendocrine tumors
- Radioactive therapy vs chemotherapy: which works better for pancreatic NETs?
- Can armored CAR t cells take down Hard-to-Treat neuroendocrine cancers?
- A simple blood draw could spot tumor relapse before scans do
- Can a radioactive drug shrink Slow-Growing tumours?