New liposomal painkiller could improve knee surgery recovery
NCT ID NCT07366905
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a long-acting form of the painkiller bupivacaine (liposomal bupivacaine) for nerve blocks in the thigh during knee surgery. Researchers aimed to find the best dose to numb sensation and block movement. 79 adults having knee surgery took part, and the results will help guide future pain management.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- liposomal bupivacaine
- What this could lead to
- If successful, this could help doctors use the right dose of liposomal bupivacaine for better pain control during knee surgery.
- What could go wrong
- This is a small, early-phase study focused on finding the right dose, not on proving effectiveness. Results may not apply to all patients or surgeries.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
-
79 people
The number who actually took part.
- Started
-
Feb 2026
- Finished
-
Apr 2026
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 85 years
- Sex
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Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adults aged 18 to 85 years * Scheduled for elective unilateral lower limb surgery * Unilateral ultrasound-guided femoral nerve block clinically indicated as part of routine perioperative anesthesia and analgesia management * Ability to clearly distinguish between the blocked (operated) limb and the contralateral (non-blocked) limb for sensory and pain assessments * Ability to understand the study procedures and provide written informed consent * Ability to cooperate with sensory and motor assessments, including visual analog scale (VAS) scoring and quadriceps muscle strength testing Exclusion Criteria: * Known allergy or hypersensitivity to bupivacaine, amide-type local anesthetics, or any component of liposomal bupivacaine * Infection at or near the planned injection site * Coagulopathy or clinically significant bleeding disorder, or anticoagulant/antiplatelet therapy incompatible with peripheral nerve block * Pre-existing neurological deficits, neuropathy, or motor weakness affecting either lower limb that could interfere with sensory or motor assessments * Severe hepatic dysfunction or other conditions that increase the risk of local anesthetic systemic toxicity * Pregnancy or breastfeeding * Emergency surgery * Inability to complete study assessments or comply with study procedures
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Department of Anesthesiology,the Second Affiliated Hospital of Hainan Medical University
Haikou, Hainan, China
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