Could simple leg exercises restore balance and blood flow after chemotherapy?
NCT ID NCT07756073
First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time
Summary
This trial tests whether combining Buerger's exercises—leg movements that stimulate blood flow—with proprioceptive drills that train balance and coordination can help elderly patients who have nerve damage from chemotherapy. The study includes 70 people aged 65 and older with chemotherapy-induced peripheral neuropathy, who will do the exercises three times a week for eight weeks. Researchers will measure changes in postural stability, foot perfusion, pain, and quality of life to see if this drug-free approach can reduce fall risk and improve daily functioning.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- A combination of Buerger's exercises (leg positioning to boost blood flow) and proprioceptive drills (balance and coordination training), performed 3 times weekly for 8 weeks under physiotherapist supervision.
- What this could lead to
- If effective, this exercise combo could offer a drug-free way to improve balance, reduce fall risk, and enhance foot circulation in older cancer survivors with nerve damage from chemotherapy.
- What could go wrong
- This is a small, early-stage trial, and results may not apply to all patients. The exercises require physical effort and could be challenging for frail elderly individuals, though they are supervised.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 70 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jul 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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65 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Aged 65 years or older * Diagnosed with CIPN for at least 3 months * Demonstrating impaired postural stability (BBS ≤ 48 or ≥2 falls in the past year) * Medically cleared for exercise * Cognitively intact (MMSE ≥ 24) * Willing and able to give consent Exclusion Criteria: * Severe peripheral arterial disease (ABI \< 0.5) * Severe postural hypotension or positional syncope * Recent orthopedic procedures or fractures (past 6 months) * Vestibular or cerebellar disorders * Uncontrolled systemic diseases * Cognitive impairment (MMSE \< 24) * Concurrent participation in another structured balance or vascular program * Lower limb ulcers or active infection * Severe visual impairment * Intolerance to positional exercises
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
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