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Tiny camera down the windpipe: new hope for kids with tough pneumonia?

NCT ID NCT07421440

Knowledge-focused Sponsor: Mansour Gomaa Mohammed Saleh Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jul 21, 2026 · Updated 3 times

Summary

This study looks at whether a procedure called flexible bronchoscopy can help doctors find the exact germ causing pneumonia in children who are not getting better with standard antibiotics. The study will include 58 children in the intensive care unit at a hospital in Cairo. If it works, this approach could lead to more targeted treatments and better outcomes for these seriously ill children.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
flexible fiberoptic bronchoscopy with bronchoalveolar lavage
What this could lead to
If successful, this could show that bronchoscopy helps doctors identify the exact germ causing stubborn pneumonia, leading to more targeted and effective treatments for critically ill children.
What could go wrong
This is a small, single-center study with only 58 children, so results may not apply to all patients. The procedure itself carries risks like bleeding or infection, and it may not always find a clear cause.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

70 people

The number who actually took part.

Started

Feb 2023

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Children aged 3 months to 18 years admitted to the Pediatric Intensive Care Unit at Abu El-Reesh Children's Hospital, Cairo University, with resistant pneumonia who underwent flexible fiberoptic bronchoscopy with bronchoalveolar lavage as part of their diagnostic evaluation

Ages

3 months to 14 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * \- Children aged more than 3 months and less than 14 years. * Admitted to Pediatric Intensive Care Unit (PICU). * Severe pneumonia defined as cough or difficulty breathing with at least one of the following: * Oxygen saturation \< 90% on pulse oximetry * Severe respiratory distress * General danger signs (inability to drink, lethargy, convulsions) * No clinical or radiological improvement after at least five days of first-line broad-spectrum antibiotic therapy. * Informed consent obtained from parent or legal guardian. Exclusion Criteria: * Age less than 3 months or more than 14 years. * Absolute contraindication to flexible bronchoscopy (severe refractory hypoxemia, hemodynamic instability, uncorrected bleeding disorder). * refusal of informed consent by parents or legal guardian

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Conditions

The condition(s) this trial relates to.

pneumonia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pneumonia Resistant pneumonia Resistant pneumonia in critically ill pedaitric patients

Contacts and locations

Locations

  • Abu Elreesh children hospital , faculty of medicine , cairo university

    Cairo, Cairo Governorate, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.