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Could a 30-Minute ZAP during surgery help heal nerves?

NCT ID NCT06687460

Disease control Sponsor: National Cheng-Kung University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving a short, 30-minute electrical stimulation to the damaged nerve during hand surgery can help it regrow and restore function better than surgery alone. It involves 21 adults with acute nerve injuries between the elbow and wrist. Researchers will measure nerve signals and hand function over time to see if the stimulation makes a difference.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
brief electrical stimulation
What this could lead to
If it works, this could offer a simple, low-cost way to improve hand function recovery after nerve repair surgery.
What could go wrong
This is a very small early-stage trial with only 21 participants, so results may not apply widely. The benefit of electrical stimulation for nerve regeneration is still unproven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 21 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2024

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 and older * Acute peripheral nerve rupture between the elbow and wrist * Acute rupture of the median or ulnar nerve * Patients who have signed a valid written consent for surgery and trials * Patients with acute transection or compression of the median nerve or ulnar nerve resulting in impaired hand motor function.Patients with hand motor dysfunction secondary to nerve compression are defined as those who meet all of the following criteria: 1. Evidence of muscle atrophy (including thenar muscles, hypothenar muscles, and interosseous muscles) 2. Positive Froment's sign 3. Positive Wartenberg's sign 4. Presence of ape hand deformity 5. Abnormal findings on electromyography (Needle EMG), such as abnormal insertional activity, increased spontaneous activity, or abnormal motor unit recruitment 6. Classified as Grade IIA, IIB, or III according to the McGowan classification system for severity of nerve compression Exclusion Criteria: * History of injury or other causes leading to muscle and joint dysfunction in the affected area * Patients with radial nerve damage * Diabetes * History of arrhythmia * Stroke * Multiple sclerosis * Hereditary peripheral neuropathy * Amyotrophic lateral sclerosis (ALS) * Patients with a pacemaker * Presence of local infection at the wound site * Pregnant or breastfeeding women * Patients deemed unsuitable for enrollment by a physician

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Electrical stimulation Peripheral nerve regeneration

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • National Cheng Kung University Hospital

    Tainan, Taiwan, 704302, Taiwan

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