Could a simple breathing trick ease POTS symptoms?
NCT ID NCT00962728
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether breathing through a special resistance device can help people with Postural Orthostatic Tachycardia Syndrome (POTS) stand up longer and reduce the rapid heart rate that happens when they stand. Researchers will measure heart rate changes and symptom relief in 30 adults diagnosed with POTS. The goal is to find a simple, non-drug way to improve daily life for those affected.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 30 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jul 2009
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Diagnosed with postural tachycardia syndrome by the Vanderbilt Autonomic Dysfunction Center * Increase in heart rate ≥ 30 beats/min with position change from supine to standing (10 minutes) * Chronic symptoms consistent with POTS that are worse when upright and get better with recumbence * Able and willing to provide informed consent Exclusion Criteria: * Overt cause for postural tachycardia (such as acute dehydration) * Inability to give, or withdrawal of, informed consent * Pregnant * Other factors which in the investigator's opinion would prevent the subject from completing the protocol
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Vanderbilt University Medical Center
Nashville, Tennessee, 37232, United States
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