Brain-Computer interface targets anxiety in heart patients

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participants will be aged 18 years or older and will provide written informed consent. * Participants will have chronic coronary syndrome (CCS) with prior coronary stent implantation more than 6 months before enrollment. * Participants will meet high ischemic risk (HIR) criteria by either of the following: * Percutaneous coronary intervention (PCI) performed more than 6 months earlier for acute coronary syndrome (ACS), including unstable angina, non-ST-segment elevation myocardial infarction, or ST-segment elevation myocardial infarction, with implantation of at least 1 coronary stent; or * PCI performed more than 6 months earlier for a non-ACS indication, together with at least 1 of the following risk factors: * diabetes mellitus; * diffuse multivessel coronary artery disease involving all 3 major coronary vessels; * chronic kidney disease with creatinine clearance less than 50 mL/min (recommended to be calculated using the Cockcroft-Gault formula); * prior stent thrombosis; * peripheral arterial disease; * complex PCI, defined by at least 1 of the following: * only patent remaining coronary vessel or left main coronary artery stenting; * implantation of at least 3 stents or treatment of at least 3 lesions; * bifurcation lesion treated with a 2-stent strategy; * total stent length greater than 60 mm; * PCI for chronic total occlusion. * Participants will meet DSM-5 diagnostic criteria for an anxiety disorder, confirmed by structured psychiatric interview. * Participants will have a Hamilton Anxiety Rating Scale (HAMA) score of 16 or higher. * Participants will have a 17-item Hamilton Depression Rating Scale (HAMD-17) score lower than 17. * Participants will not have used psychotropic medication, including antidepressants, anxiolytics, or antipsychotics, within 1 month before enrollment; prior psychotropic medication use will not itself exclude participation, provided that a washout period has been completed before enrollment and the medication history is documented. Exclusion Criteria: * Participants will be excluded if they have severe congestive heart failure (New York Heart Association class IV). * Participants will be excluded if they have moderate-to-severe valvular heart disease. * Participants will be excluded if they have a history of atrial fibrillation. * Participants will be excluded if they have unstable blood pressure, defined as systolic blood pressure greater than 180 mmHg or less than 90 mmHg. * Participants will be excluded if they are pregnant or breastfeeding. * Participants will be excluded if they have active or recent (within 6 months) severe systemic disease, including any of the following: * cerebrovascular disease, including stroke or transient ischemic attack; * dementia or severe cognitive impairment; * hyperthyroidism; * active pulmonary disease; * active malignant tumor. * Participants will be excluded if they have suicidal or homicidal risk based on clinical interview. * Participants will be excluded if they have other severe psychiatric disorders, including but not limited to: * psychotic disorders, such as hallucinations or delusions; * bipolar disorder.