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Scientists zap brains to unlock secrets of memory

NCT ID NCT05204381

Knowledge-focused Sponsor: University of North Carolina, Chapel Hill Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested how rhythmic brain stimulation (TMS) affects memory and brain connectivity in 71 healthy adults aged 18-35. Participants performed a memory task while receiving timed pulses to the front and top of the brain. The goal was to see if changing brain wave patterns could improve or disrupt working memory.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
rhythmic transcranial magnetic stimulation (TMS)
What this could lead to
If successful, this could help scientists understand how brain rhythms control memory and attention, possibly pointing toward future treatments for cognitive disorders.
What could go wrong
This is a small, early-stage study focused on basic brain function, not a treatment. Results may not apply to real-world conditions or lead to any therapy.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

71 people

The number who actually took part.

Started

Jan 2022

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Between the ages of 18 and 35 * Right-handed * Able to provide informed consent * Have normal to corrected vision without color blindness * Willing to comply with all study procedures and be available for the duration of the study Speak and understand English * Participants will be invited back to the second session only if they are able to perform the task. The criteria for demonstrating the cognitive process of interest is that participants must show a benefit to their working memory percent correct during trials with an informative retro-cue relative to trials with an uninformative neutral cue Exclusion Criteria: * Attention Deficit Hyperactivity Disorder (ADHD) (currently under treatment) * Neurological disorders and conditions, including, but not limited to: * History of epilepsy * Seizures (except childhood febrile seizures) Dementia * History of stroke * Parkinson's disease * Multiple sclerosis * Cerebral aneurysm * Brain tumors * Medical or neurological illness or treatment for a medical disorder that could interfere with study participation (e.g., unstable cardiac disease, HIV/AIDS, malignancy, liver or renal impairment) * Prior brain surgery * Any brain devices/implants, including cochlear implants and aneurysm clips * History of current traumatic brain injury * Failure to pass a colorblindness test * (For females) Pregnancy or breast feeding * Anything that, in the opinion of the investigator, would place the participant at increased risk or preclude the participant's full compliance with or completion of the study

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Executive function

Contacts and locations

Locations

  • University of North Carolina at Chapel Hill

    Chapel Hill, North Carolina, 27599, United States

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