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Brain zap plus exercise may fight frailty in seniors

NCT ID NCT07346989

Symptom relief Sponsor: University of Valencia Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jul 07, 2026 · Updated 3 times

Summary

This study tests whether a non-invasive brain stimulation technique called rTMS, combined with a therapeutic exercise program, can improve physical function and quality of life in prefrail older adults aged 65-90. Researchers will measure changes in frailty status, walking speed, and brain plasticity markers. The goal is to find a safe, effective way to prevent decline and help seniors maintain independence.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
non-invasive brain stimulation (rTMS) plus therapeutic exercise
What this could lead to
If it works, this could point toward a safe, drug-free way to help older adults stay stronger and more independent.
What could go wrong
This is an early-stage study with only 120 participants, so results may not apply to everyone. The effect may be small or no better than exercise alone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2026

Expected to finish

Jul 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

65 to 90 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age between 65 -90 years old * Meet 1-2 frailty criteria, according to Fried's Criteria. * Ability to understand instructions (Mini-Mental State Examination \>23 points). * Signing of the informed consent. Exclusion Criteria: * History of stroke within the past 6 months or hospital admission for any reason within the past 3 months. * Alterations of the central or peripheral nervous system * Alterations of the vestibular system * Concomitant diseases * Have a neurological pathology, cardiovascular musculoskeletal that contraindicates physical activity * Epilepsy or history, medications that lower the seizure threshold * Cardiac pacemaker, endocranial and hearing implants * History of severe headaches * Uncontrolled intracranial or arterial hypertension * Heart and/or respiratory failure * Implanted medication pump * Skin lesions (psoriasis, eczema) * Serious head surgeries * Completing less than 80% of training sessions

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Prefrail elderly

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Valencia

    RECRUITING

    Valencia, Valencia, 46010, Spain

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