Brain scans reveal salt sensors in hypertension mystery
NCT ID NCT06094816
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study uses MRI to watch how the brain reacts to a sudden increase of salt in the blood. Researchers will compare people whose blood pressure changes with salt intake to those whose blood pressure stays steady. The goal is to understand which brain regions sense salt and how they work, not to test a new treatment.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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About 120 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Mar 2024
- Expected to finish
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Jul 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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40 to 60 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age: \> 40 years or \< 60 years * Blood pressure: \> 100/60 mmHg or \< 140/90 mmHg * BMI: \> 18.5 kg/m2 or \< 35 kg/m2 * Serum potassium: \> 3.5 mmol/L or \< 5.5 mmol/L * No history of cardiovascular, renal, metabolic, or neurological disease Exclusion Criteria: * Age: \< 40 years or \> 60 years * Blood pressure: \< 100/60 mmHg or \> 140/90 mmHg * BMI: \< 18.5 kg/m2 or \> 30 kg/m2 * Serum potassium: \< 3.5 mmol/L or \> 5.5 mmol/L * Abnormal ECG * History of - cardiovascular, cancer, metabolic, respiratory, renal disease * Hormone replacement therapy * Current tobacco or nicotine use * Pregnant or nursing mothers * Major brain injury (concussions do not count) * Clinically diagnosed psychiatric or neurological disorder * Clinically diagnosed anxiety or depression * Psychiatric, neurological, anxiety or depression medications * Hypertension medications * Sulfonamide drug allergy * Contra-indications to MRI (implants, metal, etc) * Claustrophobia
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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University of Delaware
RECRUITINGNewark, Delaware, 19713, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Could gut bacteria explain why salt raises blood pressure?
- Salt's secret role: could your immune system be driving blood pressure?
- Salt showdown: new study puts blood pressure to the test
- New drug targets immune system to fight Salt-Sensitive hypertension
- Scientists map Brain's salt sensors in blood pressure study