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Brain implant reads and stops freezing episodes in Parkinson's patients

NCT ID NCT06642519

Disease control Sponsor: University of Toronto Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tests a brain-computer interface that records brain activity and delivers stimulation to stop freezing of gait in people with Parkinson's disease. Ten participants who are already scheduled for deep brain stimulation surgery will have an additional electrode placed on the brain's surface. The device will first learn to detect brain signals linked to freezing episodes, then deliver targeted stimulation to prevent them.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
brain stimulation via electrocorticography (ECoG) and brain-machine interface
What this could lead to
If it works, this could lead to a new way to treat freezing of gait in Parkinson's disease by using brain stimulation triggered by the patient's own brain signals.
What could go wrong
This is a very small early study with only 10 people, so results may not apply to everyone. The approach is complex and may not work in real-world settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 10 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2025

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * PD fulfilling standard criteria for bilateral STN/GPi DBS surgery * Debilitating FOG in the off-medication condition with only partial response to levodopa (defined as the witnessed occurrence of FOG during the on phase of the pre-DBS L-dopa challenge) * Clinically established FOG (i.e. reported by patient/caregiver AND seen by the examiner in the clinic) * Able to provide informed consent, comply with study protocol Exclusion Criteria: * Prior ischemic stroke, intracranial hemorrhage, or intracerebral mass * Previous brain surgery * Other disorders potentially biasing assessment * Absence of FOG in the medication on condition (a population already manageable with current standard of treatment).

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Conditions

The condition(s) this trial relates to.

Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Freezing of gait symptoms in Parkinson'S disease Parkinson disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Movement Disorders Centre - Toronto Western Hospital

    Toronto, Ontario, M5T 2S8, Canada

More trials for these conditions

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