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Fertility drugs may rewire brain activity, new study suggests

NCT ID NCT06910293

Knowledge-focused Sponsor: ART Fertility Clinics LLC Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tracks brain activity in 15 healthy women during their natural menstrual cycle and again during a fertility treatment cycle. Using fMRI scans at three key points, researchers compare how natural hormones versus injected fertility drugs impact brain connectivity and dynamics. The goal is to better understand the neurological effects of ovarian stimulation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help understand how fertility treatments affect brain function, potentially guiding safer protocols.
What could go wrong
This is a very small, early observational study (15 women) with no treatment being tested. Results may not apply to broader populations or reveal clear patterns.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 15 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2025

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Young (age range 25-35), healthy, naturally cycling women with a normal BMI, who want to undergo ovarian stimulation for oocyte vitrification.

Ages

25 to 35 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age group: 25 - 35 years old * BMI: 20 - 30 * Anti-Mullerian Hormone (AMH): 1.3 - 5.9 ng/ml * Regular Menstrual Cycle: 26-35 days * In case of previous use of hormonal contraception: wash-out period of 3 month * Meet standard safety and eligibility criteria for MRI scanning, including the absence of contraindications such as metallic implants, claustrophobia, or other medical conditions that preclude MRI Exclusion Criteria: * History of ovarian surgery * Pathology of the ovaries * Mental health disorders * Use of medication influencing brain function * Ongoing use of hormonal contraception (this would include OCP, but also patches and Mirena containing IUD)

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Brain connectivity Brain function Neural activity Neurodynamics

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • ART Fertility Clinics LLC

    RECRUITING

    Abu Dhabi, Abu Dhabi Emirate, 00000, United Arab Emirates

  • ART Fertility Clinics LLC

    RECRUITING

    Abu Dhabi, Abu Dhabi Emirate, 60202, United Arab Emirates

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