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Brain scans reveal why eating triggers Binge-Purge cycles

NCT ID NCT05995496

Knowledge-focused Sponsor: Icahn School of Medicine at Mount Sinai Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how eating changes brain activity related to self-control in women with bulimia nervosa. Researchers will use MRI scans to compare brain responses after fasting versus after a meal. The goal is to understand why control breaks down, leading to cycles of bingeing and purging.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could reveal why people with bulimia lose control after eating, pointing toward new psychological or behavioral treatments.
What could go wrong
This is an early observational study, not a treatment trial. It may not lead to direct therapies, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 150 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2023

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Female * Aged 18 to 45 years * Current BMI greater than or equal to 18.5kg/m2 but under 30kg/m2 * Right-handed * English-speaking Additional Inclusion Criteria for Women with Bulimia Nervosa: * Meet DSM-5 criteria for bulimia nervosa Exclusion Criteria: * Medical instability * Ongoing medical treatment, medical condition, or psychiatric disorder that may interfere with study variables or participation * Shift work * Pregnancy, planned pregnancy, or lactation during the study period * Allergy to any of the ingredients in or unwillingness to consume the standardized meal or unwillingness to drink water during the fasting period * Any contraindication for fMRI

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Conditions

The condition(s) this trial relates to.

bulimia nervosa

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bulimia nervosa

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Center of Excellence in Eating and Weight Disorders at the Icahn School of Medicine at Mount Sinai

    RECRUITING

    New York, New York, 10029, United States

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