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Mind-Controlled therapy could help restore smiles in facial palsy patients

NCT ID NCT07327710

Disease control Sponsor: Nanjing Medical University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests whether a non-invasive brain-computer interface combined with mild electrical brain stimulation can improve facial movement in people with peripheral facial palsy. Thirty adults aged 18-70 with moderate to severe facial weakness will receive up to 20 sessions over 4 weeks. The goal is to see if this technology is safe and helps restore facial symmetry and muscle control.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
non-invasive brain-computer interface combined with transcranial direct current stimulation
What this could lead to
If it works, this could offer a new, drug-free way to help people with facial palsy regain better control of their facial muscles.
What could go wrong
This is a very small, early-stage trial with only 30 participants, so results may not apply to everyone. Side effects like skin tingling, fatigue, or headache are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2025

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Aged 18-70 years, regardless of sex. Unilateral peripheral facial nerve palsy. House-Brackmann (HB) grade II-VI. Able to cooperate with target facial movement tasks and provide written informed consent, with intact cognitive function and good communication ability. Good skin condition, with no severe skin lesions or facial skin grafts; no implanted electronic devices such as cardiac pacemakers or deep brain stimulators, to avoid electrophysiological interference. Non-pregnant and non-lactating women, in accordance with regulatory requirements for minimal-risk research. Exclusion Criteria: Open facial wounds, active infections, significant skin lesions, or a history of severe allergy. Severe cognitive impairment, psychiatric disorders, or inability to comply with study procedures. Occurrence of serious adverse events or withdrawal at the patient's request. Pregnant or lactating women, or patients unable to use appropriate contraceptive measures during the study period.

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Conditions

The condition(s) this trial relates to.

Bell's palsy facial nerve disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Brain computer interface Peripheral facial palsy Pulsed radiofrequency Transcranial direct current stimulation

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • The Second Peoples's Hospital of Changzhou, the Third Affiliated Hospital of Nanjing Medical University

    Changzhou, Jiangsu, 213000, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.