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Scientists hunt for brain repair clues in discarded birth tissues

NCT ID NCT06866184

Knowledge-focused Sponsor: University of Aberdeen Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused This study
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at tiny particles called extracellular vesicles (EVs) released by stem cells from birth tissues like the placenta and umbilical cord. Researchers want to find which EVs are best at repairing aging or damaged brain cells in lab models. The goal is to understand how these vesicles work, not to test a treatment in people yet. The study is currently on hold.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
mesenchymal stem cell-derived extracellular vesicles (MSC-EVs)
What this could lead to
If successful, this research could point toward new ways to treat age-related brain diseases like dementia using stem cell byproducts.
What could go wrong
This is a very early, lab-based study using cell models, not humans. It is currently suspended, and findings may not translate to real treatments for years, if ever.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Jan 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Healthy females undergoing a planned C/S for a single neonate (full term)

Ages

16 to 45 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * • Women aged 16 years and older with a good understanding of English * Women undergoing a non-emergency elective C/S for a single neonate * Pregnancies ≥30 weeks of gestation * Taking no regular medication other than pregnancy related vitamins or supplements * Participant must be able to give fully informed written consent. Exclusion Criteria: * • Significant pregnancy complications or abnormal ultrasound scans * Placenta expected to be sent to pathology following delivery (common reasons for this: baby admitted to neonatal unit, abnormal cord blood pH levels, abruption, peripartum sepsis, or severe growth restriction) * Any significant disease or disorder in the mother including the following: autoimmune conditions (Lupus, scleroderma, Hashimoto's, RA, arthritis etc), cancer, diabetes, genetic abnormalities, infection (Hepatitis, HIV, EBV, Herpes, STDs, chronic bacterial), liver or kidney disease, neurological conditions or COVID within past 6 months. * Currently part of another CTIMP study. * Drugs or smoking during pregnancy, or excessive alcohol consumption. * Unable to understand English as no translator will be available for this study. * Unable to give fully informed consent

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Caesarean delivery

How to take part

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  1. The places running it

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  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Aberdeen Royal Infirmary

    Aberdeen, United Kingdom

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