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Botox for stiff knees? small trial tests new use after ACL repair

NCT ID NCT05008731

Symptom relief Sponsor: GCS Ramsay Santé pour l'Enseignement et la Recherche Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a botulinum toxin injection could help people who develop hamstring tightness after anterior cruciate ligament (ACL) reconstruction. The goal was to see if the injection could restore full knee extension. The trial was terminated early and only enrolled 13 participants, so results are limited.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

13 people

The number who actually took part.

Started

Jul 2024

Finished

Feb 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient over 18 years of age * Patient who has read and signed the consent form for participation in the study * Patient operated on for primary ACL ligamentoplasty with or without meniscal repair * Patient with reducible flatus \>10° at 1 month post ligamentoplasty Exclusion Criteria: * Revision ligamentoplasty * Multi-ligament knee * Patient under court protection, guardianship or trusteeship * Patient not affiliated to the French social security system * Patient participating in another therapeutic protocol * Pregnant woman or woman of childbearing age without effective contraception * Patient unable to understand the informed information and/or to give written informed consent: dementia, psychosis, disturbed consciousness, non-French speaking patient * Patient with known hypersensitivity to botulinum toxin * Patient with peripheral neuromuscular dysfunction or pronounced atrophy of the semitendinosus muscle * Patient treated with anticoagulants, chloroquine (or hydroxychloroquine) * Patient treated in the previous seven days with antibiotics or muscle relaxants (such as tubocurarine)

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hamstring contractures

Contacts and locations

Locations

  • Clinique du Sport

    Paris, 75005, France

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Other studies related to the condition(s) this trial covers.