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Botox shots aim to steady shaky hands in common tremor disorder

NCT ID NCT05216250

Symptom relief Sponsor: AbbVie Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether BOTOX injections can safely reduce hand tremors in people with essential tremor, a condition that makes everyday tasks like writing or drinking difficult. About 174 adults aged 18 to 80 received either BOTOX or a placebo injection over three 12-week cycles. Researchers measured changes in tremor-related disability and tracked side effects to see if the treatment helps without serious risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

174 people

The number who actually took part.

Started

Apr 2022

Finished

Feb 2025

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosis of essential tremor in accordance with modified Tremor Investigation Group (TRIG) criteria as described in the protocol. * TREDS-Revised Scale (1-4 scale, whole numbers) unilateral score of \>= 3 for the Tremor Disability Scale (TREDS) on any of the 7 unilateral items; no more than a single item score of 1 among the 7 unilateral items in the dominant limb. * TETRAS activities of daily living (ADL) (recorded on a 0-4 scale, whole numbers) minimum score of \>= 3 on any of the 5 unilateral items; no more than a single item score of \<=1 among the 5 unilateral items in the dominant limb. * At least one of the following criteria must also be met: * TETRAS UL score (0-4 scale, with 0.5 increments) of \> 2 in the dominant limb on at least one of the 3 maneuvers OR * TETRAS Archimedes spiral task score (0-4 scale, with 0.5 increments) of \> 2 in the dominant limb Exclusion Criteria: * Any uncontrolled clinically significant medical condition other than the one under study. * Any medical condition that may put the participant at increased risk with exposure to BOTOX Purified Neurotoxin Complex.

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Conditions

The condition(s) this trial relates to.

essential tremor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Upper limb essential tremor (ul et)

Contacts and locations

Locations

  • Accel Research Site-NeuroStudies /ID# 239881

    Decatur, Georgia, 30030-2627, United States

  • Accel Research Sites - Neurology and Neurodiagnostics of Alabama, LLC /ID# 240472

    Hoover, Alabama, 35244-5700, United States

  • Atrium Health Wake Forest Baptist Medical Center /ID# 233550

    Winston-Salem, North Carolina, 27157-0001, United States

  • Barrow Neurological Institute - Dignity Health St. Joseph's Hosp and Medical Ctr /ID# 231731

    Phoenix, Arizona, 85013, United States

  • Baylor College of Medicine /ID# 231624

    Houston, Texas, 77030, United States

  • CDC Research Institute LLC /ID# 242744

    Port Saint Lucie, Florida, 34952-7539, United States

  • Centricity Research /ID# 240587

    Halifax, Nova Scotia, B3S 1N2, Canada

  • Charter Research - Winter Park /ID# 241568

    Orlando, Florida, 32803-1839, United States

  • Coastal Clinical Research Specialists /ID# 240471

    Jacksonville, Florida, 32205-8275, United States

  • Coastal Clinical Research Specialists /ID# 240897

    Fernandina Beach, Florida, 32034-4779, United States

  • Dayton Center for Neurological Disorders /ID# 233737

    Centerville, Ohio, 45459-3811, United States

  • Dent Neurologic Institute - Amherst /ID# 255665

    Amherst, New York, 14226, United States

  • Emory University / Emory Brain Health Center /ID# 231911

    Atlanta, Georgia, 30329-2206, United States

  • Gamma Therapeutic Center /ID# 232547

    Greenfield, Wisconsin, 53228-1321, United States

  • Genge Partners /ID# 251546

    Montreal, Quebec, H4A 3T2, Canada

  • Henry Ford Health Medical Center - Jackson /ID# 231400

    Jackson, Michigan, 49201-1852, United States

  • Integrated Neurology Services - Falls Church /ID# 233545

    Falls Church, Virginia, 22043-2367, United States

  • Kansas Institute of Research /ID# 231623

    Overland Park, Kansas, 66211-1363, United States

  • Lahey Hospital & Medical Center /ID# 233232

    Burlington, Massachusetts, 01805, United States

  • Loma Linda University /ID# 230905

    Loma Linda, California, 92354, United States

  • Marshfield Clinic - Marshfield /ID# 233191

    Marshfield, Wisconsin, 54449, United States

  • Medical University of South Carolina /ID# 233538

    Charleston, South Carolina, 29425, United States

  • Neurology - Triad /ID# 239806

    Winston-Salem, North Carolina, 27103-6984, United States

  • New England Institute for Clinical Research /ID# 238404

    Stamford, Connecticut, 06905, United States

  • Oregon Health and Science University /ID# 231581

    Portland, Oregon, 97239, United States

  • Parkinson's Disease and Movement Disorders Center of Boca Raton /ID# 231677

    Boca Raton, Florida, 33486, United States

  • Texas Movement Disorder Specialists, PLLC /ID# 242524

    Georgetown, Texas, 78628-4126, United States

  • Texas Neurology /ID# 250428

    Dallas, Texas, 75214, United States

  • The Orthopedic Foundation /ID# 232234

    New Albany, Ohio, 43054-8167, United States

  • Thomas Jefferson University Hospital /ID# 232614

    Philadelphia, Pennsylvania, 19107, United States

  • Toronto Western Hospital /ID# 231587

    Toronto, Ontario, M5T 2S8, Canada

  • Tufts Medical Center /ID# 239929

    Boston, Massachusetts, 02111-1552, United States

  • UNC Hospitals Neurology Clinic - Chapel Hill /ID# 238857

    Chapel Hill, North Carolina, 27517-4400, United States

  • Univ Kansas Med Ctr /ID# 231166

    Kansas City, Kansas, 66160, United States

  • Univ Texas HSC San Antonio /ID# 232615

    San Antonio, Texas, 78229-3901, United States

  • University of Arizona /ID# 239781

    Tucson, Arizona, 85724, United States

  • University of Colorado - Anschutz Medical Campus /ID# 239869

    Aurora, Colorado, 80045-2527, United States

  • University of Pittsburgh MC /ID# 233735

    Pittsburgh, Pennsylvania, 15260, United States

  • University of Texas Southwestern Medical Center /ID# 239770

    Dallas, Texas, 75390-7208, United States

  • Vancouver Coastal Health Authority - University of British Columbia /ID# 240356

    Vancouver, British Columbia, V6T 1Z9, Canada