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BOTOX face slimming: new study shows promise for a sharper jawline

NCT ID NCT06387394

Symptom relief Sponsor: AbbVie Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 26, 2026 · Updated 2 times

Summary

This study tested whether BOTOX injections can safely reduce the size of the masseter muscle, which can make the lower face look wide. About 200 adults with noticeable muscle prominence received either BOTOX or a placebo. The goal was to see if the treatment improved appearance and satisfaction without serious side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

202 people

The number who actually took part.

Started

Apr 2024

Finished

Nov 2025

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participant meets the following criteria: * Bilateral Grade 4 or Grade 5 Masseter Muscle Prominence (MMP) (identical grades for left and right sides of the face), as determined at by the investigator using the Masseter Muscle Prominence Scale (MMPS). * Bilateral Grade 4 or Grade 5 MMP (identical grades for left and right sides of the face), as determined by the participant using the Masseter Muscle Prominence Scale - Participant (MMPS-P). * Investigator and participant scoring of MMPS and MMPS-P must be the same. * Body mass index (BMI) ≤ 30 kg/m\^2 using the calculation: BMI = weight (kg)/height (m)\^2. Exclusion Criteria: * Excess lower facial fat, jowling, loose or lax skin in lower face, or parotid gland prominence that could interfere with MMPS or MMPS-P grading. * Asymmetry of left and right sides of the face that could prevent identical MMPS or MMPS-P grading on both sides of the face. * History of or current temporomandibular disorder (TMJD), or presence of signs/symptoms of possible TMJD.

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Conditions

The condition(s) this trial relates to.

masticatory muscles, hypertrophy of

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Masseter muscle prominence

Contacts and locations

Locations

  • Austin Institute for Clinical Research - Pflugerville /ID# 248217

    Pflugerville, Texas, 78660, United States

  • Ava T. Shamban MD - Santa Monica. /ID# 248886

    Santa Monica, California, 90404-2208, United States

  • Bellaire Dermatology Associates /ID# 248221

    Bellaire, Texas, 77401, United States

  • Centricity Research Dublin Multispecialty /ID# 248484

    Dublin, Ohio, 43016, United States

  • Clarkston Dermatology /ID# 248888

    Clarkston, Michigan, 48346, United States

  • Coleman Center For Cosmetic Dermatologic Surgery /ID# 249827

    Metairie, Louisiana, 70006, United States

  • Cosmetic Laser Dermatology /ID# 248215

    San Diego, California, 92121-2119, United States

  • DMR Research PLLC /ID# 248485

    Westport, Connecticut, 06880, United States

  • Dallas Plastic Surgery Institute /ID# 248220

    Dallas, Texas, 75231, United States

  • Delricht Research /ID# 249825

    New Orleans, Louisiana, 70115, United States

  • Edwin F. Williams III, MD FACS of LATHAM P.C. D/B/A THE REJUVA CENTER /ID# 248887

    Latham, New York, 12110, United States

  • Mayo Clinic Arizona /ID# 248883

    Phoenix, Arizona, 85054, United States

  • Skin Care and Laser Physicians of Beverly Hills /ID# 248223

    Los Angeles, California, 90069, United States

  • Skin Laser and Surgery Specialists of NY and NJ /ID# 251501

    Hackensack, New Jersey, 07601-1997, United States

  • Skin and Cancer Associates, LLP /ID# 248209

    Miami, Florida, 33137-3254, United States

  • SkinDC /ID# 248885

    Arlington, Virginia, 22209, United States

  • Susan H. Weinkle MD /ID# 252063

    Bradenton, Florida, 34209-5642, United States

  • Tennessee Clinical Research Center /ID# 248486

    Nashville, Tennessee, 37215-2885, United States

  • Total Skin and Beauty Dermatology Center /ID# 248218

    Birmingham, Alabama, 35205, United States

  • Wilmington Dermatology Center /ID# 250651

    Wilmington, North Carolina, 28403, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.