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New CT method could slash radiation in bone scans

NCT ID NCT01800084

Knowledge-focused Sponsor: Centre Hospitalier Universitaire de Nīmes Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a newer CT reconstruction method (ASIR) can produce bone SPECT-CT images as good as the standard method (FBP) while using less radiation. Researchers enrolled 75 patients scheduled for a SPECT-CT exam. They compared image quality by measuring signal and noise in the spine and aorta. The goal was to see if ASIR could reduce radiation exposure without sacrificing image clarity.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Adaptive statistical iterative reconstruction (ASIR) and filtered back projection (FBP) reconstruction methods
What this could lead to
If successful, this could allow doctors to use lower radiation doses during bone SPECT-CT scans without losing image quality, making scans safer for patients.
What could go wrong
This is a small, completed study focused on image quality, not on patient health outcomes. The results may not apply to all types of scans or patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

75 people

The number who actually took part.

Start date

Aug 2013

Finished

May 2014

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * The patient must have given his/her informed and signed consent * The patient must be insured or beneficiary of a health insurance plan * A SPECT-CT exam is scheduled for the patient * The patient is able to withstand an extended position with the arms behind the head for 15 minutes (i.e. patient is able to undergo a SPECT-CT exam) Exclusion Criteria: * The patient is participating in another study * The patient is in an exclusion period determined by a previous study * The patient is under judicial protection, or any kind of guardianship * The patient refuses to sign the consent * The patient has a contra-indication for a treatment necessary for this study (patient is not able to withstand an extended position with the arms behind the head for 15 minutes) * It is impossible to correctly inform the patient * The patient is pregnant, parturient, or breastfeeding * Emergency situations * Presence of osteosynthesis material (or any other material that would generate an artifact during SPECT-CT) in the spine * Patient behaviour hampers image acquisition

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Spect-CT

Contacts and locations

Locations

  • CHU de Nîmes - Hôpital Universitaire Carémeau

    Nîmes, Gard, 30029, France

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