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Could bone marrow heal a torn ACL without surgery?

NCT ID NCT06353503

Cure Sponsor: abdulmajeed hammadi Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 14, 2026 · Last updated Sep 15, 2026 · Updated 1 time

Summary

Researchers are testing whether injecting a concentrated form of a patient's own bone marrow into the knee can help a completely torn anterior cruciate ligament heal. The study enrolls 20 people aged 20 to 55 with a confirmed ACL tear. Participants receive a single injection of bone marrow aspirate concentrate into the knee joint under ultrasound guidance, and researchers track knee stability and MRI changes over time.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
autologous bone marrow aspirate concentrate, a preparation of the patient's own bone marrow injected into the injured knee
What this could lead to
If it works, this could offer a way to heal a torn ACL using a person's own cells, possibly avoiding reconstructive surgery and its long recovery.
What could go wrong
This is a small early study with 20 people, so results may not hold up in larger trials. The injection may not repair the ligament, and knee injection carries small risks of infection or bleeding.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

20 people

The number who actually took part.

Started

Apr 2024

Finished

Sep 2026

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 55 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1- Confirmed diagnosis of complete or partial ACL tear via clinical examination and imaging studies. 2\. Aged between 20 and 55 years, to encompass the typical age range of patients with sports-related ACL injuries. Exclusion Criteria: 1- Patients with a history of bleeding disorders, as this could complicate the aspiration and injection procedures. 2\. Individuals with a history of malignancy, due to the potential risks associated with growth factors present in BMAC. 3\. Critically ill patients or those with comorbidities

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Conditions

The condition(s) this trial relates to.

Anterior Cruciate Ligament Injuries

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anterior cruciate ligament tear

Contacts and locations

Locations

  • Ministry of Health

    Baghdad, Iraq, 964, Iraq

More trials for these conditions

Other studies related to the condition(s) this trial covers.