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Iron Overload's hidden toll on bones revealed in new study

NCT ID NCT01556360

Knowledge-focused Sponsor: Rennes University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study followed 100 adults with genetic hemochromatosis (a condition causing too much iron in the body) for 3 years to see how their bone health changed. Researchers measured bone density and checked for fractures and joint problems. The goal was to understand if iron overload weakens bones over time, even with treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help doctors better predict and manage bone problems in people with genetic hemochromatosis.
What could go wrong
This is an observational study, not a treatment trial. It only describes what happens, so it won't directly improve bone health. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

100 people

The number who actually took part.

Started

Jul 2008

Finished

Jun 2014

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patient with genetic hemochromatosis diagnosed in western France hospitals

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients between 18 and 80 years * C282 homozygosity Exclusion Criteria: * corticosteroids during the last 3 months * following treatments during the last 6 months : anabolic steroids, growth hormone, hormone therapy for menopause, tibolone, raloxifene. * following treatments during inclusion or in the last 6 month : teriparatide, parathormone, fluor, strontium ranelate, biphosphonate. * cancer or evolutionary hemopathy (including monoclonal gammopathy) * pregnancy at inclusion time * treated osteoporosis * patient in wich follow up seems hard * inclusion in another study incompatible with this one

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Conditions

The condition(s) this trial relates to.

hereditary hemochromatosis Iron Overload

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Genetic hemochromatosis

Contacts and locations

Locations

  • Angers University Hospital

    Angers, 49933, France

  • Brest University Hospital

    Brest, 29609, France

  • Nantes University Hospital

    Nantes, 44093, France

  • Orleans Regional Hospital

    Orléans, 45100, France

  • Poitiers University Hospital

    Poitiers, 86021, France

  • Rennes University Hospital

    Rennes, 35033, France

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