New lung cancer vaccine trial launches for advanced patients

NCT ID NCT05142189

Recruiting now Disease control Sponsor: BioNTech SE Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated Jun 20, 2026 · Updated 29 times

Summary

This early-stage trial is testing a new cancer vaccine called BNT116, alone or with other drugs, in people with advanced non-small cell lung cancer. The main goal is to find a safe dose and check for side effects. About 320 participants will be enrolled across several groups, including those with different stages of lung cancer.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Contacts and locations

Show contact details

Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Adana City Training and Research Hospital
RECRUITING

Adana, 01370, Turkey (Türkiye)
Ankara City Hospital
RECRUITING

Ankara, 06800, Turkey (Türkiye)
Cambridge University Hospitals NHS Foundation Trust
RECRUITING

Cambridge, CB2 0QQ, United Kingdom
Cancer Research SA
RECRUITING

Adelaide, South Australia, 5000, Australia
Clinexpert Ltd
RECRUITING

Gyöngyös, 3200, Hungary
Complejo Hospitalario Universitario de Santiago de Compostela (CHUS) - Hospital Clinico Universitario (University Clinical Hospital)
RECRUITING

Santiago de Compostela, 15706, Spain
Dokuz Eylul Medical School
COMPLETED

Izmir, 35330, Turkey (Türkiye)
Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital
RECRUITING

Ankara, 06200, Turkey (Türkiye)
Ege University School of Medicine Tulay Aktas Oncology Hospital
RECRUITING

Izmir, 35100, Turkey (Türkiye)
Guy's and St Thomas NHS Foundation Trust
RECRUITING

London, SE1 9RT, United Kingdom
Haceteppe Hospital
RECRUITING

Ankara, 06100, Turkey (Türkiye)
Hospital Universitario Fundacion Jimenez Diaz
RECRUITING

Madrid, 28040, Spain
Hospital Universitario Vall d'Hebron
RECRUITING

Barcelona, 08035, Spain
Hospital Universitario Virgen Macarena
RECRUITING

Seville, 41009, Spain
Hospital Universitario y Politecnico La Fe
RECRUITING

Valencia, 46026, Spain
ICON-PRA Budapest, Fázis 1 Vizsgálóhely
COMPLETED

Budapest, 1077, Hungary
Institut Catala d'Oncologia Badalona, Hospital Germans Trias I Pujol
RECRUITING

Badalona, 08916, Spain
Johns Hopkins Sidney Kimmel Comprehensive Cancer Center
RECRUITING

Baltimore, Maryland, 21287, United States
Koc University Hospital
RECRUITING

Istanbul, 34010, Turkey (Türkiye)
Krankenhaus Nordwest GmbH - Institut Fuer Klinisch-Onkologische Forschung (IKF)
RECRUITING

Frankfurt, 60488, Germany
MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
MD Anderson Cancer Center
RECRUITING

Madrid, 28033, Spain
Monash Health
RECRUITING

Clayton, Victoria, 3168, Australia
NEXT Virginia
RECRUITING

Fairfax, Virginia, 22031, United States
NZOZ Medpolonia Sp. Z o.o
RECRUITING

Poznan, 60-693, Poland
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy
WITHDRAWN

Warsaw, 02-781, Poland
National Institute of Oncology
RECRUITING

Budapest, 1122, Hungary
Norton Cancer Institute
RECRUITING

Louisville, Kentucky, 40202, United States
Royal North Shore Hospital
RECRUITING

Sydney, New South Wales, 2065, Australia
START Madrid - CIOCC. Grupo Hospital de Madrid (HM) - Centro Integral Oncologico Clara Campal (CIOCC)
RECRUITING

Madrid, 28050, Spain
Scientia Clinical Research
RECRUITING

Randwick, New South Wales, 2031, Australia
Semmelweis Egyetem ÁOK Belgyógyászati és Onkológiai Klinika
RECRUITING

Budapest, 1083, Hungary
The Clatterbridge Cancer Centre NHS Foundation Trust
RECRUITING

Liverpool, L7 8YA, United Kingdom
The Newcastle Upon Tyne Hospitals NHS Foundation Trust
RECRUITING

Newcastle upon Tyne, NE7 7DN, United Kingdom
Universitaetsmedizin der Johannes Gutenberg Universitaet Mainz KoeR
RECRUITING

Mainz, 55131, Germany
University College London Hospitals NHS Foundation Trust
RECRUITING

London, W1T 7HA, United Kingdom
University Medical Center Hamburg-Eppendorf
RECRUITING

Hamburg, 20246, Germany
University Medical Faculty Oncology Institute
RECRUITING

Istanbul, 34093, Turkey (Türkiye)
University of Kentucky Chandler Medical Center
RECRUITING

Lexington, Kentucky, 40536, United States
Universitätsklinikum Köln
RECRUITING

Cologne, 50937, Germany
Uniwersyteckie Centrum Kliniczne
RECRUITING

Gdansk, 80-214, Poland
Velindre NHS Trust
RECRUITING

Cardiff, CF14 2TL, United Kingdom
Warminsko Mazurskie Centrum Chorob Pluc w Olsztynie
RECRUITING

Olsztyn, 10-357, Poland
Yeditepe University
RECRUITING

Istanbul, 34718, Turkey (Türkiye)

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

BNT116 (a cancer vaccine) alone or combined with other drugs like cemiplimab, docetaxel, or targeted therapies

What this could lead to

If successful, this could point toward a new treatment option for advanced lung cancer, potentially improving outcomes for patients who have few alternatives.

What could go wrong

This is a very early (Phase 1) trial focused on safety and dosing, so it is too soon to know if BNT116 will work. Side effects are unknown, and many early-stage trials do not lead to approved treatments.

Conditions

The condition(s) this trial relates to.

autosomal dominant Parkinson disease 4 lethal congenital contracture syndrome 2 multiple endocrine neoplasia type 2A non-small cell lung carcinoma type 1 diabetes mellitus 12

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON SMALL CELL LUNG CANCER NON-SMALL CELL LUNG CANCER