Blood test may predict clot risk after joint surgery
NCT ID NCT03634124
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at whether a blood test done before hip or knee replacement surgery can predict the risk of developing deep vein thrombosis (DVT), a dangerous blood clot. Researchers measured thrombin generation in 146 patients. The goal was to see if the test could identify who is at higher risk, potentially leading to better prevention strategies.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If this test works, it could help doctors identify patients at higher risk for blood clots after hip or knee replacement surgery, allowing for personalized prevention.
- What could go wrong
- This is a completed study with 146 participants, so results are preliminary. The test may not be accurate enough for routine use, and further larger studies are needed.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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146 people
The number who actually took part.
- Started
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Feb 2019
- Finished
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Oct 2023
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * The patient must have his consent and signed the consent form. * The patient must affiliated or a beneficiary of a health insurance plan. * The patient is at least 18 years old * Patient with an indication of total hip prosthesis or total knee replacement surgery set unilateral Exclusion Criteria: * The patient is participating in another interventional study. * The patient is in an exclusion period determined by a previous study. * Minor patients, people in emergency situations. * The patient is under the protection of justice, guardianship or curatorship. * The patient refuses to sign the consent. * It is not possible to inform the patient. * The patient is pregnant, parturient, or breastfeeding. * The patient has a contraindication (or incompatible drug combination) to drug thromboprophylaxis applied according to good clinical practice and recommendations of learned societies * Long-term anticoagulant therapy for personal thrombotic history. * Known hemorrhagic disease. * Haemorrhagic risk perceived during the consultation of preoperative anesthesia, leading to modify / develop the usual thromboprophylaxis. * Chronic liver disease. * Chronic renal failure with calculated clearance \<30 ml / min. * Extreme body mass index: \<18 kg.m-2 or\> 40 kg.m-2 * total hip prosthesis or total knee prosthesis in the immediate aftermath of a bone fracture. * total hip prosthesis resumption. * Installation of more than one joint prosthesis. * Surgery in the previous 3 months. * Infective push in the previous 3 months. * Indication of haemostatic treatment for abnormal haemorrhagic risk. * Severe impairment of renal function with a calculated clearance \<30 ml / min. * Contraindication (allergic, metabolic, other ...) to usual drug thromboprophylaxis. * Condition requiring dosage adjustment of drug thromboprophylaxis. * Indication to put in place intermittent pneumatic compression for perioperative thromboprophylaxis.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Nimes University Hospital
Nîmes, 30029, France
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Other studies related to the condition(s) this trial covers.
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