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Blood test may predict clot risk after joint surgery

NCT ID NCT03634124

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether a blood test done before hip or knee replacement surgery can predict the risk of developing deep vein thrombosis (DVT), a dangerous blood clot. Researchers measured thrombin generation in 146 patients. The goal was to see if the test could identify who is at higher risk, potentially leading to better prevention strategies.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If this test works, it could help doctors identify patients at higher risk for blood clots after hip or knee replacement surgery, allowing for personalized prevention.
What could go wrong
This is a completed study with 146 participants, so results are preliminary. The test may not be accurate enough for routine use, and further larger studies are needed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

146 people

The number who actually took part.

Started

Feb 2019

Finished

Oct 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * The patient must have his consent and signed the consent form. * The patient must affiliated or a beneficiary of a health insurance plan. * The patient is at least 18 years old * Patient with an indication of total hip prosthesis or total knee replacement surgery set unilateral Exclusion Criteria: * The patient is participating in another interventional study. * The patient is in an exclusion period determined by a previous study. * Minor patients, people in emergency situations. * The patient is under the protection of justice, guardianship or curatorship. * The patient refuses to sign the consent. * It is not possible to inform the patient. * The patient is pregnant, parturient, or breastfeeding. * The patient has a contraindication (or incompatible drug combination) to drug thromboprophylaxis applied according to good clinical practice and recommendations of learned societies * Long-term anticoagulant therapy for personal thrombotic history. * Known hemorrhagic disease. * Haemorrhagic risk perceived during the consultation of preoperative anesthesia, leading to modify / develop the usual thromboprophylaxis. * Chronic liver disease. * Chronic renal failure with calculated clearance \<30 ml / min. * Extreme body mass index: \<18 kg.m-2 or\> 40 kg.m-2 * total hip prosthesis or total knee prosthesis in the immediate aftermath of a bone fracture. * total hip prosthesis resumption. * Installation of more than one joint prosthesis. * Surgery in the previous 3 months. * Infective push in the previous 3 months. * Indication of haemostatic treatment for abnormal haemorrhagic risk. * Severe impairment of renal function with a calculated clearance \<30 ml / min. * Contraindication (allergic, metabolic, other ...) to usual drug thromboprophylaxis. * Condition requiring dosage adjustment of drug thromboprophylaxis. * Indication to put in place intermittent pneumatic compression for perioperative thromboprophylaxis.

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Conditions

The condition(s) this trial relates to.

venous thromboembolism Venous Thrombosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Nimes University Hospital

    Nîmes, 30029, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.