New study pinpoints safer blood pressure dosing for moms with preeclampsia
NCT ID NCT06158022
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at 60 women with preeclampsia having a C-section to find the best doses of two drugs (phenylephrine and norepinephrine) to prevent dangerously low blood pressure after spinal anesthesia. The goal was to identify doses that work in 90% of patients. The findings could help doctors manage blood pressure more precisely during delivery, reducing risks for both mother and baby.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Phenylephrine and norepinephrine (vasopressors to raise blood pressure)
- What this could lead to
- If successful, this could establish precise dosing guidelines to prevent dangerous drops in blood pressure during C-section in women with preeclampsia, improving safety for mothers and babies.
- What could go wrong
- This is a small, completed dose-finding study (60 participants), not a large trial. The results may not apply to all patients or settings, and the drugs themselves can cause side effects like slow heart rate.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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60 people
The number who actually took part.
- Started
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Oct 2024
- Finished
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May 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 45 years
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * 18-45 years * Primipara or multipara * Singleton pregnancy ≥32 weeks * American Society of Anesthesiologists physical status classification II to III * Scheduled for cesarean section under spinal anesthesia Exclusion Criteria: * Baseline blood pressure ≥160 mmHg * Body height \< 150 cm * Body weight \> 100 kg or body mass index (BMI) ≥ 40 kg/m2 * Eclampsia or chronic hypertension * Hemoglobin \< 7g/dl * Fetal distress, or known fetal developmental anomaly
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
General hospital of Ningxia University
Yinchuan, Ningxia, 750004, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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