Massive study aims to find best methods to cut blood loss in hip, knee, and shoulder replacements
NCT ID NCT07500350
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study will analyze data from over 1,600 patients undergoing hip, knee, or shoulder replacement surgery to understand what factors influence blood loss. Researchers will look at surgical techniques, anesthesia methods, and medications to see which approaches lead to less bleeding. The goal is to identify the best strategies to reduce blood loss and improve patient outcomes.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this study could identify the best surgical and anesthetic techniques to minimize blood loss during joint replacement surgery.
- What could go wrong
- This is an observational study, not a treatment trial. It will not directly test a new drug or procedure, so it may not lead to immediate changes in practice.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 1,683 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jul 2026
An estimate. Start dates often move.
- Expected to finish
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Mar 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients of both sexes who have undergone total knee replacement (unilateral or bilateral), unicompartmental and total knee replacement (unilateral or bilateral), and total shoulder replacement.
- Ages
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Children (under 18), adults (18 to 64) and older adults (65 and over)
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion criteria: \- Adult patients in ASA Class I-II-III undergoing prosthetic surgery, as a first-time implant Exclusion criteria: * Patients who did not receive tranexamic acid prophylaxis (pre-operative and post- operative doses) and are therefore not comparable with the vast majority of cases. * Reintervention, as bleeding depends on a variable that is not constant, namely the initial implant
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Milan, Milan, Italy
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