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Bladder cancer drug combo study halted early – what we know

NCT ID NCT04586244

First seen Nov 01, 2025 · Last updated May 20, 2026 · Updated 23 times

Summary

This study tested different drug combinations given before surgery to remove the bladder in people with muscle-invasive bladder cancer who couldn't take the standard chemotherapy drug cisplatin. The trial was stopped early, and only 30 people took part. The main goal was to see how the drugs changed immune cells in the tumor, but not enough data was collected to draw clear conclusions.

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Contacts and locations

Locations

  • Azienda Ospedaliera Universitaria Integrata Verona (Ospedale Borgo Roma)

    Verona, 37124, Italy

  • Hopital Europeen Georges Pompidou (Hegp)

    Paris, 75015, France

  • Hospital Saint Louis

    Paris, 75475, France

  • Institut Gustave Roussy

    Villejuif, 94805, France

  • Istituto Di Ricovero E Cura A Carattere Scientifico (Irccs) Ospedale San Raffaele

    Milan, 20132, Italy

  • Istituto Tumori Giovanni Paolo Ii Irccs Ospedale Oncologico Bari

    Bari, 70124, Italy

  • L Azienda Ospedaliero-Universitaria Di Bologna Policlinico S. Orsola - Malpighi

    Bologna, 40138, Italy

  • Ohio State University Medical Center Division of H

    Columbus, Ohio, 43210, United States

  • Oregon Health & Science University

    Portland, Oregon, 97239-4501, United States

  • Universita Campus Bio Medico Di Roma

    Roma, 00128, Italy

  • University of Cincinnati

    Cincinnati, Ohio, 45267, United States

  • University of Iowa

    Iowa City, Iowa, 52242, United States

Conditions

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