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Gut bacteria boosts immunotherapy in kidney cancer fight?

NCT ID NCT07383441

First seen Feb 03, 2026 · Last updated Jun 17, 2026 · Updated 23 times

Summary

This phase 3 trial tests whether adding a live biotherapy called MO-03 to standard immunotherapy can help control advanced or metastatic clear cell renal cell carcinoma. MO-03 is designed to improve gut health, which may make immunotherapy work better. About 718 participants will receive either MO-03 or a placebo alongside their regular treatment. The study aims to see if this combination delays cancer progression.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Baptist Cancer Center-Grenada

    RECRUITING

    Grenada, Mississippi, 38901, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Baptist Memorial Hospital and Cancer Center-Collierville

    RECRUITING

    Collierville, Tennessee, 38017, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Baptist Memorial Hospital and Cancer Center-Desoto

    RECRUITING

    Southhaven, Mississippi, 38671, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Baptist Memorial Hospital and Cancer Center-Golden Triangle

    RECRUITING

    Columbus, Mississippi, 39705, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Baptist Memorial Hospital and Cancer Center-Memphis

    RECRUITING

    Memphis, Tennessee, 38120, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Baptist Memorial Hospital and Cancer Center-Oxford

    RECRUITING

    Oxford, Mississippi, 38655, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Baptist Memorial Hospital and Cancer Center-Union County

    RECRUITING

    New Albany, Mississippi, 38652, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Cancer Care Specialists of Illinois - Decatur

    RECRUITING

    Decatur, Illinois, 62526, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Decatur Memorial Hospital

    RECRUITING

    Decatur, Illinois, 62526, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Highlands Oncology Group

    RECRUITING

    Springdale, Arkansas, 72762, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Highlands Oncology Group - Fayetteville

    RECRUITING

    Fayetteville, Arkansas, 72703, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Highlands Oncology Group - Rogers

    RECRUITING

    Rogers, Arkansas, 72758, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Illinois CancerCare - Washington

    RECRUITING

    Washington, Illinois, 61571, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Illinois CancerCare-Bloomington

    RECRUITING

    Bloomington, Illinois, 61704, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Illinois CancerCare-Canton

    RECRUITING

    Canton, Illinois, 61520, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Illinois CancerCare-Carthage

    RECRUITING

    Carthage, Illinois, 62321, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Illinois CancerCare-Eureka

    RECRUITING

    Eureka, Illinois, 61530, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Illinois CancerCare-Galesburg

    RECRUITING

    Galesburg, Illinois, 61401, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Illinois CancerCare-Kewanee Clinic

    RECRUITING

    Kewanee, Illinois, 61443, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Illinois CancerCare-Macomb

    RECRUITING

    Macomb, Illinois, 61455, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Illinois CancerCare-Ottawa Clinic

    RECRUITING

    Ottawa, Illinois, 61350, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Illinois CancerCare-Pekin

    RECRUITING

    Pekin, Illinois, 61554, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Illinois CancerCare-Peoria

    RECRUITING

    Peoria, Illinois, 61615, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Illinois CancerCare-Peru

    RECRUITING

    Peru, Illinois, 61354, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Illinois CancerCare-Princeton

    RECRUITING

    Princeton, Illinois, 61356, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Lahey Hospital and Medical Center

    RECRUITING

    Burlington, Massachusetts, 01805, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Lahey Medical Center-Peabody

    RECRUITING

    Peabody, Massachusetts, 01960, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Mercy Hospital

    RECRUITING

    Cedar Rapids, Iowa, 52403, United States

    Contact

    Contact Phone: •••-•••-••••

  • Missouri Baptist Medical Center

    RECRUITING

    St Louis, Missouri, 63131, United States

    Contact

    Contact Phone: •••-•••-••••

  • Missouri Baptist Sullivan Hospital

    RECRUITING

    Sullivan, Missouri, 63080, United States

    Contact

    Contact Phone: •••-•••-••••

  • NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro

    RECRUITING

    Jonesboro, Arkansas, 72401, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Oncology Associates at Mercy Medical Center

    RECRUITING

    Cedar Rapids, Iowa, 52403, United States

    Contact

    Contact Phone: •••-•••-••••

  • Parkland Health Center - Farmington

    RECRUITING

    Farmington, Missouri, 63640, United States

    Contact

    Contact Phone: •••-•••-••••

  • Saint Francis Medical Center

    RECRUITING

    Cape Girardeau, Missouri, 63703, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Sainte Genevieve County Memorial Hospital

    RECRUITING

    Sainte Genevieve, Missouri, 63670, United States

    Contact

    Contact Phone: •••-•••-••••

  • Southern Illinois University School of Medicine

    RECRUITING

    Springfield, Illinois, 62702, United States

    Contact

    Contact Phone: •••-•••-••••

  • Trinity Health IHA Medical Group Hematology Oncology - Brighton

    RECRUITING

    Brighton, Michigan, 48114, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Trinity Health IHA Medical Group Hematology Oncology - Canton

    RECRUITING

    Canton, Michigan, 48188, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital

    RECRUITING

    Chelsea, Michigan, 48118, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus

    RECRUITING

    Ypsilanti, Michigan, 48197, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Trinity Health Saint Mary Mercy Livonia Hospital

    RECRUITING

    Livonia, Michigan, 48154, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

Conditions

The condition(s) this trial relates to.

clear cell renal carcinoma Clear-cell metastatic renal cell carcinoma renal cell adenocarcinoma renal cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.