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Scientists dig deeper into ALK lung cancer to unlock resistance secrets

NCT ID NCT05122806

Knowledge-focused Sponsor: Groupe Francais De Pneumo-Cancerologie Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at the biological features of a specific type of lung cancer (ALK-positive) in 100 patients. Researchers will analyze tumor samples and blood tests taken at diagnosis and when the disease worsens. The goal is to learn why some treatments stop working, not to test a new therapy.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2021

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Stage IIIB/IV NSCLC non eligible to locoregional treatment with curative intent * ALK rearrangement confirmed by IHC and/or FISH or NGS according to local methods * Patient included in the EXPLORE ALK study * Age \> or = 18 years * Patient treated with first-line new generation ALKi * Patient agrees to sign an informed consent form and to collect blood samples at inclusion, first tumor evaluation and progression and for whom tumor biopsy at diagnosis is available * Patient enrolled in the french National Health Insurance program or with a third- party payer Exclusion Criteria: * Patients who do not wish to participate in Bioexalk * Patients under guardianship

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALK gene rearrangement positive Non-small cell lung cancer

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    46 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • CHU La Réunion Site Sud

    RECRUITING

    Saint-Pierre, 97410, France

  • CHU Pontchailloux

    RECRUITING

    Rennes, 35000, France

  • Centre François Baclesse

    NOT_YET_RECRUITING

    Caen, 14000, France

  • Centre Hospitalier Intercommunal de Créteil

    RECRUITING

    Créteil, 94010, France

  • Centre Hospitalier Universitaire

    NOT_YET_RECRUITING

    Angers, 49033, France

  • Centre Hospitalier d'Aix en Provence

    NOT_YET_RECRUITING

    Aix-en-Provence, 13616, France

  • Centre Hospitalier d'Annecy

    RECRUITING

    Annecy, 74374, France

  • Centre Hospitalier de Villefranche sur Saone

    RECRUITING

    Villefranche-sur-Saône, 69655, France

  • Centre Hospitalier du Morvan

    RECRUITING

    Brest, 29200, France

  • Centre Léon Bérard

    RECRUITING

    Lyon, 69373, France

  • Centre Paul Strauss

    NOT_YET_RECRUITING

    Strasbourg, 67065, France

  • Hôpital Charles Nicolle

    RECRUITING

    Rouen, 76031, France

  • Hôpital Larrey

    NOT_YET_RECRUITING

    Toulouse, 31059, France

  • Hôpital Nord

    RECRUITING

    Marseille, 13915, France

  • Hôpital d'Instruction des Armées Ste Anne

    RECRUITING

    Toulon, 83800, France

  • Hôpital de Meaux

    RECRUITING

    Meaux, 77100, France

  • Hôpital du Haut Leveque

    NOT_YET_RECRUITING

    Pessac, 33604, France

  • Hôpital du Scorff

    RECRUITING

    Lorient, 56100, France

  • Institut Lucien Neuwirth

    RECRUITING

    Saint-Priest-en-Jarez, 42271, France

  • Oncologie CH Bretagne-Atlantique

    RECRUITING

    Vannes, 56000, France

  • Oncologie CH Morlaix

    NOT_YET_RECRUITING

    Morlaix, 29600, France

  • Oncologie CLCC Jean Perrin

    NOT_YET_RECRUITING

    Clermont-Ferrand, 63000, France

  • Oncologie Centre Oscar Lombret

    NOT_YET_RECRUITING

    Lille, 59000, France

  • Oncologie Hôpital François Quesnay

    NOT_YET_RECRUITING

    Mantes-la-Jolie, 78200, France

  • Oncologie Institut Curie

    NOT_YET_RECRUITING

    Paris, 75005, France

  • Oncologie Institut Gustave Roussy

    NOT_YET_RECRUITING

    Villejuif, 94805, France

  • Oncologie Institut Paoli Calmette

    NOT_YET_RECRUITING

    Marseille, 13273, France

  • Oncologie Institut du Cancer de Montpellier

    NOT_YET_RECRUITING

    Montpellier, 34298, France

  • Pneumologie CH

    NOT_YET_RECRUITING

    Le Mans, 72000, France

  • Pneumologie CH Eure-Seine

    RECRUITING

    Évreux, 27000, France

  • Pneumologie CH Métropole Savoie

    RECRUITING

    Chambéry, 73000, France

  • Pneumologie CHD Vendée

    RECRUITING

    La Roche-sur-Yon, 85925, France

  • Pneumologie CHI

    NOT_YET_RECRUITING

    Villeneuve-Saint-Georges, 94195, France

  • Pneumologie CHR

    RECRUITING

    Orléans, 45000, France

  • Pneumologie CHU

    NOT_YET_RECRUITING

    Amiens, 80054, France

  • Pneumologie CHU Félix Guyon

    RECRUITING

    Saint-Denis, La Réunion, 97400, France

  • Pneumologie CHU Limoges

    NOT_YET_RECRUITING

    Limoges, 87042, France

  • Pneumologie Centre Hospitalier

    RECRUITING

    Pau, 64000, France

  • Pneumologie HIA

    NOT_YET_RECRUITING

    Talence, 33400, France

  • Pneumologie Hôpital Calmette

    NOT_YET_RECRUITING

    Lille, 59000, France

  • Pneumologie Hôpital Européen

    RECRUITING

    Marseille, 130003, France

  • Pneumologie Hôpital Foch

    RECRUITING

    Suresnes, 92150, France

  • Pneumologie Hôpital Mignot

    NOT_YET_RECRUITING

    Le Chesnay, 78157, France

  • Pneumologie Hôpital Sainte Musse

    NOT_YET_RECRUITING

    Toulon, 83056, France

  • Pneumologie Hôpital Yves Le Foll

    NOT_YET_RECRUITING

    Saint-Brieuc, 22000, France

  • Pneumologie Hôpital privé Jean Mermoz

    NOT_YET_RECRUITING

    Lyon, 69085, France

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