Gut health may help straighten spines: probiotic trial launches
NCT ID NCT07466511
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a daily probiotic supplement (Bifidobacterium breve) can slow the curve progression of idiopathic scoliosis in children aged 6 to 15. One hundred participants will take the probiotic or receive lifestyle education for 6 months. Researchers will measure spine curvature and quality of life to see if the supplement helps.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Bifidobacterium breve probiotic supplement
- What this could lead to
- If it works, this could point toward a simple, safe way to slow scoliosis worsening in children, reducing the need for braces or surgery.
- What could go wrong
- This is a small, early-stage trial with only 100 children. The effect may be small or nonexistent, and results may not apply to all scoliosis patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 100 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jan 2027
An estimate. Start dates often move.
- Expected to finish
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Dec 2030
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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6 to 15 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age 6 to 15 years Diagnosed with idiopathic scoliosis based on clinical evaluation and radiographic examination at the first clinic visit Skeletally immature, defined as Risser sign 0 to 3 Major Cobb angle \< 40 degrees at baseline Written informed consent provided by the participant or legal guardian Able and willing to comply with study procedures Exclusion Criteria: * Plans to relocate within the next 24 months Use of antibiotics, probiotics, hormones, immunosuppressants, or other nutritional supplements known to affect gut microbiota within the past 3 months or during the study period without investigator approval Known allergy, sensitivity, or intolerance to the investigational product or its ingredients Current or prior significant gastrointestinal disease requiring medication, or history of gastrointestinal surgery Severe gastrointestinal symptoms such as persistent heartburn or indigestion Musculoskeletal, neurodevelopmental, syndromic, or other conditions that may account for the spinal deformity History of spine surgery or major spinal injury Spinal tumor or malignant disease involving the spine Leg length discrepancy \> 20 mm Severe chronic diseases that could interfere with study participation or outcome assessment, including but not limited to diabetes, narcolepsy, or poorly controlled asthma Severe obesity, defined as BMI z-score ≥ 3
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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The Second Affiliated Hospital of Wenzhou Medical University, Zhejiang, Zhejiang 325000
Wenzhou, Zhejiang, 325600, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- A smarter brace for scoliosis: does 3D design stop curves from worsening?
- Can a Night-Time brace or targeted exercises halt scoliosis curves in teens?
- Could simple exercises replace braces for mild scoliosis?
- Your DNA may hold the key to personalized pain relief
- Which Anti-Nausea drug wins for scoliosis surgery? a Head-to-Head test
- Standing within hours of spine surgery: a new test for teen recovery