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New combo therapy targets hard-to-treat neuroendocrine cancer

NCT ID NCT06132113

First seen Nov 01, 2025 · Last updated May 01, 2026 · Updated 23 times

Summary

This early-phase study tests a new drug called BI 764532 added to standard chemotherapy for people with advanced neuroendocrine carcinoma (NEC). The goal is to find a safe dose and see if the combination helps shrink tumors. About 55 adults whose cancers have a specific marker (DLL3) will receive the treatment for up to 3 years if it works and is tolerable.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Aichi Cancer Center Hospital

    RECRUITING

    Aichi, Nagoya, 464-8681, Japan

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Cliniques Universitaires Saint-Luc

    RECRUITING

    Brussels, 1200, Belgium

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Hospital Universitari Vall d'Hebron

    RECRUITING

    Barcelona, 08035, Spain

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Hospital Universitario 12 de Octubre

    RECRUITING

    Madrid, 28041, Spain

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Hospital Universitario La Paz

    RECRUITING

    Madrid, 28046, Spain

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Hôpital Louis Pradel

    NOT_YET_RECRUITING

    Bron, 69500, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • INS Paoli-Calmettes

    RECRUITING

    Marseille, 13009, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • John Theurer Cancer Center

    RECRUITING

    Hackensack, New Jersey, 07601, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Klinikum der Universität München AÖR

    NOT_YET_RECRUITING

    München, 81377, Germany

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • National Cancer Center Hospital

    RECRUITING

    Tokyo, Chuo-ku, 104-0045, Japan

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • National Cancer Center Hospital East

    RECRUITING

    Chiba, Kashiwa, 277-8577, Japan

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Northwestern University

    NOT_YET_RECRUITING

    Chicago, Illinois, 60611, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Osaka International Cancer Institute

    RECRUITING

    Osaka, Osaka, 541-8567, Japan

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Sahlgrenska Universitetsjukhuset

    RECRUITING

    Gothenburg, 413 46, Sweden

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Universitair Medisch Centrum Groningen

    RECRUITING

    Groningen, 9713 GZ, Netherlands

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of Miami

    RECRUITING

    Miami, Florida, 33136, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of Pittsburgh Medical Center

    RECRUITING

    Pittsburgh, Pennsylvania, 15232, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Universitätsklinikum Tübingen

    RECRUITING

    Tübingen, 72076, Germany

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Winship Cancer Institute

    RECRUITING

    Atlanta, Georgia, 30322, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.