New hope for GIST patients: drug combo targets resistant tumors
NCT ID NCT06208748
First seen Oct 31, 2025 · Last updated May 22, 2026 · Updated 29 times
Summary
This study tests a combination of two drugs, bezuclastinib and sunitinib, in 40 adults with advanced gastrointestinal stromal tumors (GIST) that continued to grow despite sunitinib treatment alone. The goal is to see if the combination can slow cancer progression and to identify genetic changes linked to drug resistance. Participants receive both drugs orally, and researchers track tumor response and survival.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Dana Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Fox Chase Cancer Center
Philadelphia, Pennsylvania, 19111, United States
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Oregon Health & Science University
Portland, Oregon, 97239, United States
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Sylvester Comprehensive Cancer Center, University of Miami
Miami, Florida, 33136, United States
Conditions
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