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Study aims to solve debate over best ventilator setting to keep lungs open after surgery

NCT ID NCT07211074

Knowledge-focused Sponsor: State Budgetary Healthcare Institution, National Medical Surgical Center N.A. N.I. Pirogov, Ministry of Health of Russia Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

After surgery with general anesthesia, parts of the lungs can collapse, causing low oxygen. Doctors use a breathing machine setting called PEEP to keep lungs open, but the best level is unclear. This study looked back at 450 patients to see which PEEP level was linked to less lung collapse and low oxygen, using lung ultrasound to check. The goal is to find a simple, safe way to choose the best PEEP for each patient.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help doctors choose the best breathing machine setting to reduce lung collapse and low oxygen after surgery.
What could go wrong
This is a retrospective study, meaning researchers only looked back at past data. It cannot prove cause and effect, and results may not apply to all patients or surgeries.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

450 people

The number who actually took part.

Started

Sep 2025

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consists of 450 adult patients who underwent surgical procedures under general anesthesia with mechanical ventilation. Data will be collected from patients treated at the Department of Anesthesiology and Resuscitation of the National Medical and Surgical Center n.a. N.I. Pirogov. The cohort will be formed using a time-stratified randomization method to ensure a representative sample over the study period. All included patients will have a normal lung ultrasound before their procedure. The population will be divided based on the method of airway protection: * patients managed with an endotracheal tube (ETT). * patients managed with a laryngeal mask (LM).

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients undergoing surgical intervention under general anesthesia with mechanical ventilation. * Airway protection managed with either an endotracheal tube or a laryngeal mask. * A normal baseline ultrasound of the posterior-basal lung regions, corresponding to a score of 0 on the lung ultrasound scale. Exclusion Criteria: * Patients undergoing cardiac or thoracic surgery. * Presence of a perioperatively identified pneumothorax. * Inability to obtain adequate ultrasound visualization of the target lung zones. * Presence of hydrothorax. * Confirmed perioperative pulmonary aspiration. * Presence of any pathological findings on the initial baseline ultrasound of the posterior-basal lung regions. * Requirement for massive blood transfusion during the operation. * Patients undergoing surgery on the diaphragm. * Prolonged residual sedation lasting more than 2 hours post-operation

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Lung ultrasound Postoperative atelectasis Postoperative pulmonary complications (PPCS)

Contacts and locations

Locations

  • Pirogov National Medical and Surgical Cente

    Moscow, 105203, Russia

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