Can benadryl help kids with autism sleep better?
NCT ID NCT05501678
First seen Nov 12, 2025
Summary
This study tests whether diphenhydramine (Benadryl) can help children and teens with autism fall asleep faster and sleep more soundly. Twenty-six participants aged 8 to 17 will receive either Benadryl or a placebo in a crossover design, with sleep measured by brain waves and activity monitors. The goal is to see if this common allergy medicine can ease sleep problems in autism.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
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Contact
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Locations
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Stanford University
RECRUITINGStanford, California, 94305-5719, United States
Contact
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
diphenhydramine (Benadryl)
What this could lead to
If it works, this could point toward a simple, short-term sleep aid for children with autism who have trouble falling asleep.
What could go wrong
This is a small early-phase trial with only 26 participants. Diphenhydramine may cause drowsiness or other side effects, and results may not apply to all children with autism.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.