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Can brain scans unlock hidden effects of becker muscular dystrophy?

NCT ID NCT07740057

Knowledge-focused Sponsor: Institut de Myologie, France Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 31, 2026 · Last updated Jul 31, 2026

Summary

This study looks at how the absence of a protein called Dp140 in people with Becker muscular dystrophy might affect the brain, thinking, and muscle function. Researchers will use brain and muscle imaging, along with cognitive and psychological tests, to explore these connections. The goal is to gather detailed information that could help future research and improve understanding of the disease.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
This research could improve understanding of how Becker muscular dystrophy affects the brain and thinking, potentially guiding future treatments and care.
What could go wrong
This is an observational study, so it won't test a treatment. Results may not apply to all patients, and the findings are exploratory.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 75 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Dec 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Fifty patients will be included, including 25 patients having the cerebral Dp140 isoform (Dp140+) and 25 patients lacking the cerebral Dp140 isoform (Dp140-). A same number (n=25) of age-matched healthy volunteers will be included as well.

Ages

18 to 50 years

Sex

Male participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Genetically confirmed diagnosis of Becker muscular dystrophy * Ambulant * Signed ICF Exclusion Criteria: * Individuals presenting contraindications to MRI * History of allergy to contrast product * Individuals with history of neurological diseases interfering with the study * Individuals with concomitant medical conditions that could interfere with the study outcomes * subjects who suffer from any type of cancer (or on cancer treatment) * obese subjects: BMI\>35 * subjects with cardiac (left-ventricular ejection fraction \<40%) and/or respiratory insufficiency (forced vital capacity \< 50%) and/or normal ECG * Individuals who are not yet or insufficiently stabilized on psychiatric medication * Any medical and social condition that may interfere with the study at the discretion of the medical coordinator * Guardianship

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Conditions

The condition(s) this trial relates to.

Becker muscular dystrophy Duchenne muscular dystrophy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Becker muscular dystrophy

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Institute of Mythology

    Paris, 75651, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.