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Engineered donor cells take aim at stubborn childhood leukemia

NCT ID NCT06934382

First seen Nov 01, 2025 · Last updated Jun 19, 2026 · Updated 27 times

Summary

This early-phase study tests a treatment called BEAM-201, made from donor immune cells engineered to attack cancer cells in people with T-cell acute lymphoblastic leukemia or lymphoma that has returned or not responded to standard therapy. Up to 33 children and young adults (ages 0–29) will receive the cells to find a safe dose and see if the cancer shrinks or disappears. The goal is to control the disease, not necessarily cure it, and participants will be closely monitored for side effects.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Children's Hospital of Philadelphia

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

The condition(s) this trial relates to.

lymphoma Precursor T-Cell Lymphoblastic Leukemia-Lymphoma refractory precursor T-lymphoblastic lymphoma/leukemia T lymphoblastic leukemia/lymphoma T-cell acute lymphoblastic leukemia T-cell leukemia T-cell non-Hodgkin lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.