Ancient oil could be new hope for stuffy nose sufferers
NCT ID NCT07266688
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a nasal spray made from pistacia lentiscus oil (Bactorinol) in 120 adults with vasomotor rhinitis, a chronic condition causing nasal congestion and runny nose. Participants used the spray or a saline placebo for 20 days. The goal was to see if the oil spray improves nasal airflow and quality of life better than saline.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Pistacia lentiscus oil (Bactorinol nasal spray)
- What this could lead to
- If it works, this could offer a natural, non-drug option for people with vasomotor rhinitis to breathe easier and feel better.
- What could go wrong
- This is a small, completed trial with only 120 people. The results may not apply to everyone, and the improvement might be no better than saline spray.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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120 people
The number who actually took part.
- Started
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Dec 2025
- Finished
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Apr 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 75 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Male or female patients aged 18 to 70 years. * Confirmed diagnosis of vasomotor rhinitis. * Ability to understand the study procedures and provide written informed consent. * Ability to follow study instructions. * Availability to undergo scheduled evaluations. Exclusion Criteria: * Pregnant or breastfeeding women. * Stenosing deviation of the nasal septum. * Current or recurrent episodes of epistaxis. * History of nasal endoscopic surgery within the past 6 months. * Use of systemic antibiotics within the previous 30 days. * Known hypersensitivity to any component of the study products. * Concomitant topical medications applied to the nasal mucosa. * Participation in another clinical trial or completion of another trial within the last month. * Failure or unwillingness to provide informed consent.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Università di Urbino Carlo Bo
Urbino, Pesaro E Urbino, 61029, Italy