Last-resort virus therapy takes on untreatable hip infection
NCT ID NCT07461337
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether specially designed viruses (bacteriophages) can eliminate a persistent bacterial infection in a hip replacement joint. One adult who has failed all standard surgeries and antibiotics will receive the viruses directly into the joint and through an IV for two weeks. The goal is to clear the infection and avoid further complications.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 1/2
Runs two stages together: safety and dose first, then whether the treatment works.
- Participants
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About 1 person
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Mar 2026
An estimate. Start dates often move.
- Expected to finish
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Mar 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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Children (under 18), adults (18 to 64) and older adults (65 and over)
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Diagnosis of active chronic prosthetic joint infection * Causative bacteria is susceptible to bacteriophage therapy in vitro * History of multiple failed antibiotic and surgical interventions Exclusion Criteria: * Stage 5 chronic kidney disease * Cirrhosis * A known allergy to phage products * Fever * Involvement in another clinical trial * Pregnancy
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Foothills Medical Centre, University of Calgary
Calgary, Canada
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a smarter surgery and antibiotic combo cure joint infections for good?
- Biobank aims to unlock secrets of phage therapy against superbugs
- Viruses vs. superbugs: new hope for skin infections?
- Desperate times: phage cocktail takes on Drug-Resistant lung bug
- Could a special suture cut infection risk after joint replacement?
- New drug could save infected joint implants, avoid major surgery