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Which root canal device kills more bacteria? new study aims to find out

NCT ID NCT06569329

Knowledge-focused Sponsor: Abhishek Parolia Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Sep 11, 2026 · Updated 2 times

Summary

This study tests three different devices used during root canal treatment to see which one removes the most bacteria from infected teeth. Ninety adults with dead nerves in their premolars will be randomly assigned to one of the three methods. Researchers will measure bacterial levels at several points during the procedure to compare effectiveness.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could identify the most effective device for cleaning infected root canals, potentially improving dental treatment outcomes.
What could go wrong
This is a small, early-stage study (90 participants) measuring bacterial counts, not long-term healing. Results may not apply to all tooth types or guarantee better patient outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 90 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2024

Expected to finish

Aug 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 95 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosis of pulp necrosis with apical periodontitis (AP) confirmed by pulp tests, clinical and radiographic evidence. * Tooth with no response to cold and electric pulp testing (done at screening). * Single canalled premolars with intact pulp chamber walls. * Patient must be 18 years of age or older Exclusion Criteria: * Teeth with vital pulp. * Teeth with incomplete root formation (immature with apical periodontitis). * Teeth with extensive crown destruction. * Teeth with previous endodontic treatment or intervention (pulp debridement). * Teeth with acute/ chronic apical abscess. * Teeth with internal or external resorption. * Teeth with non-odontogenic facial pain. * Teeth with periodontal pockets deeper than 4 mm. * Teeth with advanced untreated periodontal disease or recent periodontal surgery. * Teeth with mobility score greater than 2. * Teeth with a fracture or visible crack. * Patients with diabetes or immune compromised conditions. * Patients who received systemic antibiotics within the last 3 months. * Patients taking corticosteroids. * Patients who are pregnant.

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Conditions

The condition(s) this trial relates to.

dental pulp necrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dental pulp necroses

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Iowa College of Dentistry and Dental Clinics

    RECRUITING

    Iowa City, Iowa, 52242, United States

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