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Blood test could guide lung cancer treatment in major new trial

NCT ID NCT03178552

Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Sep 04, 2026 · Updated 3 times

Summary

This large study is testing several targeted therapies and immunotherapies for people with advanced non-small cell lung cancer. Instead of a tissue biopsy, a simple blood test is used to find specific genetic changes in the cancer. The goal is to see if matching the right drug to each patient's mutation can shrink tumors and delay progression. Around 1000 participants are being enrolled across multiple groups, each receiving a different drug or drug combination.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Alectinib, atezolizumab, pemetrexed, cisplatin (targeted therapy and immunotherapy drugs)
What this could lead to
If successful, this could provide more personalized treatment options for people with advanced lung cancer, potentially improving response rates and survival by matching drugs to specific mutations found in a simple blood test.
What could go wrong
This is an early-to-mid-stage trial with many different drug combinations, so results may vary. The approach relies on blood-based mutation detection, which may miss some mutations, and side effects from the drugs can be serious.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2/3

Runs two stages together: whether the treatment works, then large-scale confirmation.

Participants

About 1,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2017

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Histologically or cytologically confirmed diagnosis of unresectable Stage IIIb not amenable to treatment with combined modality chemoradiation (advanced) or Stage IV (metastatic) NSCLC * Eastern Cooperative Oncology Group (ECOG) Performance Status 0-2 * Measurable disease * Adequate recovery from most recent systemic or local treatment for cancer * Adequate organ function * Life expectancy greater than or equal to (\>/=) 12 weeks * For female participants of childbearing potential and male participants, willingness to use acceptable methods of contraception Exclusion Criteria: * Inability to swallow oral medication * Women who are pregnant or lactating * Symptomatic, untreated CNS metastases * History of malignancy other than NSCLC within 5 years prior to screening with the exception of malignancies with negligible risk of metastasis or death * Significant cardiovascular disease, such as New York Heart Association cardiac disease (Class II or greater), myocardial infarction, or cerebrovascular accident within 3 months prior to randomization, unstable arrhythmias, or unstable angina * Known active or uncontrolled human immunodeficiency virus (HIV) infection * Either a concurrent condition or history of a prior condition that places the patient at unacceptable risk if he/she were treated with the study drug or confounds the ability to interpret data from the study * Inability to comply with other requirements of the protocol

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Non-small cell lung cancer

Contacts and locations

Locations

  • ASST di Cremona - Azienda Socio Sanitaria Territoriale di Cremona

    Cremona, Lombardy, 26100, Italy

  • AVIX Investigación Clínica S.C

    Monterrey, Nuevo León, 64710, Mexico

  • Akdeniz University Medical Faculty; Medical Oncology Department

    Antalya, 07070, Turkey (Türkiye)

  • Asan Medical Center

    Seoul, 05505, South Korea

  • Ashford Cancer Center Research

    Kurralta Park, South Australia, 5037, Australia

  • Asklepios-Fachklinik Muenchen-Gauting

    Gauting, 82131, Germany

  • Asst Di Monza

    Monza, Lombardy, 20900, Italy

  • Asst Papa Giovanni XXIII

    Bergamo, Lombardy, 24128, Italy

  • Auckland City Hospital

    Auckland, 1023, New Zealand

  • Azienda Ospedaliera San Camillo Forlanini

    Rome, Lazio, 00151, Italy

  • Azienda Sanitaria Ospedaliera S Luigi Gonzaga

    Orbassano (TO), Piedmont, 10043, Italy

  • Baskent University Adana Dr. Turgut Noyan Practice and Research Hospital; Medical Oncology

    Adana, 01230, Turkey (Türkiye)

  • Beijing Cancer Hospital

    Beijing, 100142, China

  • Bradford Hill Centro de Investigaciones Clinicas

    Recoleta, 8420383, Chile

  • CHU Poitiers

    Poitiers, 86021, France

  • CHU de Toulouse - Hôpital Larrey

    Toulouse, 31059, France

  • CancerCare Manitoba

    Winnipeg, Manitoba, R3E 0V9, Canada

  • Centre Francois Baclesse

    Caen, 14076, France

  • Centre Léon Bérard

    Lyon, 69373, France

  • Centre Oscar Lambret

    Lille, 59020, France

  • Centro Integral Oncologico Clara Campal

    Madrid, 28050, Spain

  • Centrum Onkologii Instytut im.Marii Sklodowskiej-Curie

    Warsaw, 02-781, Poland

  • Chaim Sheba Medical Center

    Ramat Gan, 5262100, Israel

  • Chang Gung Medical Foundation - Linkou

    Taoyuan, 333, Taiwan

  • Chonnam National University Hwasun Hospital

    Jeollanam-do, 58128, South Korea

  • Clinica Ricardo Palma

    San Isidro, Lima 27, Peru

  • Clinica Universitaria de Navarra

    Pamplona, Navarre, 31008, Spain

  • Clinical Center Nis

    Niš, 18000, Serbia

  • Clinical Center of Serbia

    Belgrade, 11000, Serbia

  • Clinical Oncology Dispensary

    Omsk, 644013, Russia

  • Cliniques Universitaires St-Luc

    Brussels, 1200, Belgium

  • Complejo Hospitalario Universitario de Santiago (CHUS)

    Santiago de Compostela, LA Coruna, 15706, Spain

  • Comprehensive Cancer Centers of Nevada

    Las Vegas, Nevada, 89128, United States

  • Cross Cancer Institute

    Edmonton, Alberta, T6G 1Z2, Canada

  • Dartmouth Hitchcock Medical Center

    Lebanon, New Hampshire, 03756, United States

  • Faculty of Med. Siriraj Hosp.

    Bangkok, 10700, Thailand

  • First Affiliated Hospital of Medical College of Xi'an Jiaotong University

    Xi'an, 710061, China

  • Florida Cancer Specialist, North Region

    St. Petersburg, Florida, 33705, United States

  • Fudan Unviversity Shanghai Cancer Center

    Shanghai, 200032, China

  • Fujita Health University Hospital

    Toyoake-shi, 470-1192, Japan

  • Fundación CENIT para la Investigación en Neurociencias

    Buenos Aires, C1125ABD, Argentina

  • HSK Dr.-Horst-Schmidt-Kliniken Klinik für Innere Medizin III Onkologie Hämatologie und Palliativmed

    Wiesbaden, 65199, Germany

  • Hacettepe Uni Medical Faculty Hospital; Oncology Dept

    Sihhiye/Ankara, 06230, Turkey (Türkiye)

  • Health Pharma Professional Research

    Mexico City, Mexico CITY (federal District), 03100, Mexico

  • Hemato Oncología de Panamá Especializada

    Panama City, 0801, Panama

  • Hiroshima University Hospital

    Hiroshima, 734-8551, Japan

  • Hopital Caremeau

    Nîmes, 30029, France

  • Hopital Pontchaillou

    Rennes, 35033, France

  • Hopital Robert Schuman

    Nouilly, 57645, France

  • Hopital Tenon

    Paris, 75970, France

  • Hospital Angeles Tijuana

    Tijuana, Estado de Baja California, 22010, Mexico

  • Hospital Britanico de Buenos Aires

    Ciudad Autonoma Buenos Aires, C1284AEB, Argentina

  • Hospital Clínic i Provincial

    Barcelona, 08036, Spain

  • Hospital Clínico Universitario de Valencia

    Valencia, 46010, Spain

  • Hospital General Univ. de Alicante

    Alicante, 03010, Spain

  • Hospital General Universitario Gregorio Marañon

    Madrid, 28007, Spain

  • Hospital Italiano

    Buenos Aires, C1181ACH, Argentina

  • Hospital Nacional Edgardo Rebagliati Martins

    Lima, 11, Peru

  • Hospital Quiron de Madrid

    Madrid, 28223, Spain

  • Hospital Ramon y Cajal

    Madrid, 28034, Spain

  • Hospital Regional Universitario Carlos Haya

    Málaga, 29010, Spain

  • Hospital Sao Lucas - PUCRS

    Porto Alegre, Rio Grande do Sul, 90610-000, Brazil

  • Hospital Universitari Vall d'Hebron

    Barcelona, 08035, Spain

  • Hospital Universitario 12 de Octubre

    Madrid, 28041, Spain

  • Hospital Universitario Puerta de Hierro

    Madrid, 28222, Spain

  • Hospital Universitario Virgen del Rocio

    Seville, 41013, Spain

  • Hunan Cancer Hospital

    Changsha, 410013, China

  • Hôpital Européen Georges Pompidou

    Paris, 75908, France

  • ICO Badalona - Hospital Germans Trias i Pujol

    Barcelona, 08916, Spain

  • IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola

    Meldola, Emilia-Romagna, 47014, Italy

  • IUCPQ (Hôpital Laval)

    Québec, Quebec, G1V 4G5, Canada

  • Insititut Catala D'Oncologia

    L'Hospitalet de Llobregat, Barcelona, 08908, Spain

  • Institut Bergonie CLCC Bordeaux

    Bordeaux, 33000, France

  • Institute for Pulmonary Diseases of Vojvodina

    Kamenitz, 21204, Serbia

  • Instituto Nacional de Cancer - INCa

    Rio de Janeiro, 20560-120, Brazil

  • Instituto Nacional de Enfermedades Neoplasicas

    Lima, 15038, Peru

  • Instituto Peruano de Oncología y Radioterapia

    Lima, Peru

  • Instituto do Cancer do Estado de Sao Paulo - ICESP

    São Paulo, São Paulo, 01246-000, Brazil

  • Irccs Centro Di Riferimento Oncologico (CRO)

    Aviano, Friuli Venezia Giulia, 33081, Italy

  • Irccs Istituto Europeo di Oncologia (IEO)

    Milan, Lombardy, 20141, Italy

  • Istituto Nazionale per lo Studio e la Cura dei Tumori Fondazione G. Pascale

    Naples, Campania, 80131, Italy

  • Jewish General Hospital

    Montreal, Quebec, H3T 1E2, Canada

  • Juntendo University Hospital

    Tokyo, 113-8431, Japan

  • Kanagawa Cancer Center

    Kanagawa, 241-8515, Japan

  • Kanazawa University Hospital

    Ishikawa, 920-8641, Japan

  • Kaohsiung Chang Gung Memorial Hospital

    Kaohsiung City, 83301, Taiwan

  • Kindai University Hospital

    Osaka, 589-8511, Japan

  • Klinikum Chemnitz gGmbH

    Chemnitz, 09116, Germany

  • Kyorin University Hospital

    Tokyo, 181-8611, Japan

  • Kyushu University Hospital

    Fukuoka, 812-8582, Japan

  • Lakeridge Health Center

    Oshawa, Ontario, L1G 2B9, Canada

  • London Health Sciences Centre · Victoria Hospital

    London, Ontario, N6A 5W9, Canada

  • Marmara University Pendik Training and Research Hospital; Medikal Onkoloji

    Istanbul, 34890, Turkey (Türkiye)

  • Medikal Park Izmir Hospital

    Kar??yaka, 35575, Turkey (Türkiye)

  • Medipol University Medical Faculty; Oncology Department

    Istanbul, 34214, Turkey (Türkiye)

  • Meir Medical Center

    Kfar Saba, 4428164, Israel

  • Montefiore Medical Center

    The Bronx, New York, 10461, United States

  • Moscow City Oncology Hospital #62

    Moscovskaya Oblast, Moscow Oblast, 143423, Russia

  • Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School

    Nanjing, 210008, China

  • National Cancer Center

    Gyeonggi-do, 10408, South Korea

  • National Cancer Centre

    Singapore, 169610, Singapore

  • National Hospital Organization Kyushu Cancer Center

    Fukuoka, 811-1395, Japan

  • National Hospital Organization Kyushu Medical Center

    Fukuoka, 810-8563, Japan

  • National Hospital Organization Yamaguchi - Ube Medical Center

    Yamaguchi, 775-0241, Japan

  • National Taiwan Uni Hospital

    Taipei, 100, Taiwan

  • National University Hospital

    Singapore, 119228, Singapore

  • Niigata Cancer Center Hospital

    Niigata, 951-8566, Japan

  • Niigata University Medical & Dental Hospital

    Niigata, 951-8520, Japan

  • Oncologico Potosino

    San Luis Potosí City, San Luis Potosí, 78250, Mexico

  • Oncosite - Centro de Pesquisa Clinica Em Oncologia Ltda

    Ijuí, Rio Grande do Sul, 98700-000, Brazil

  • Oregon HSU

    Portland, Oregon, 97210, United States

  • Prince of Songkla University

    Hat Yai, 90110, Thailand

  • Prince of Wales Hosp

    Shatin, Hong Kong

  • Princess Margaret Cancer Center

    Toronto, Ontario, M5G 1Z5, Canada

  • Principal Military Clinical Hospital n.a. N.N. Burdenko

    Moscow, Moscow Oblast, 105229, Russia

  • Queen Mary Hospital

    Hong Kong, Hong Kong

  • Rabin MC

    Petah Tikva, 4941492, Israel

  • Rambam Health Care Campus

    Haifa, 3109601, Israel

  • Rocky Mountain Cancer Center

    Denver, Colorado, 80218, United States

  • Royal North Shore Hospital

    St Leonards, New South Wales, 2065, Australia

  • Royal Victoria Regional Health Centre

    Barrie, Ontario, L4M 6M2, Canada

  • S-Pb clinical scientific practical center of specialized kinds of medical care (oncological)

    Saint Petersburg, Sankt-Peterburg, 197758, Russia

  • SCRI Florida Cancer Specialists South

    Fort Myers, Florida, 33901, United States

  • Saga University Hospital

    Saga, 849-8501, Japan

  • Sarah Cannon Research Institute / Tennessee Oncology

    Chattanooga, Tennessee, 37404, United States

  • Saskatoon Cancer Centre

    Saskatoon, Saskatchewan, SK S7N 4H4, Canada

  • Sendai Kousei Hospital

    Miyagi, 981-0914, Japan

  • Seoul National University Hospital

    Seoul, 03080, South Korea

  • Shandong Cancer Hospital

    Jinan, 250117, China

  • Shikoku Cancer Center

    Matsuyama, 791-0280, Japan

  • Shizuoka Cancer Center

    Shizuoka, 411-8777, Japan

  • Sichuan Cancer Hospital

    Chengdu, 610041, China

  • Soroka Medical Center

    Beersheba, 8410101, Israel

  • Sourasky / Ichilov Hospital; Dept. of Oncology

    Tel Aviv, 6423906, Israel

  • St. Luke's University Health network

    Bethlehem, Pennsylvania, 18015, United States

  • Sunnybrook Health Sciences Centre

    Toronto, Ontario, M4N 3M5, Canada

  • Taipei Veterans General Hospital

    Taipei, 112, Taiwan

  • The Cancer Institute Hospital of JFCR

    Tokyo, 135-8550, Japan

  • The First Affiliated Hospital of Guangzhou Medical University Pharmacy

    Guangzhou, 510120, China

  • The Prince Charles Hospital

    Chermside, Queensland, 4032, Australia

  • The Second Affiliated Hospital to Nanchang University

    Nanchang, 330006, China

  • The second Xiangya hospital of central south university

    Changsha, 410100, China

  • Thoraxklinik Heidelberg gGmbH

    Heidelberg, 69126, Germany

  • Tohoku University Hospital

    Miyagi, 980-8574, Japan

  • Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital

    Bunkyō City, 113-8677, Japan

  • Trakya University Medical Faculty Research And Practice Hospital Medical Oncology Department

    Edirne, 22770, Turkey (Türkiye)

  • UC Davis

    Sacramento, California, 95817, United States

  • UZ Brussel

    Brussels, 1090, Belgium

  • UZ Leuven Gasthuisberg

    Leuven, 3000, Belgium

  • University Hospital Kyoto Prefectural University of Medicine

    Kyoto, 602-8566, Japan

  • University Hospital Medical Center Bezanijska kosa

    Belgrade, 11080, Serbia

  • University of Kentucky

    Lexington, Kentucky, 40536, United States

  • Uniwersyteckie Centrum Kliniczne, Klinika Onkologii i Radioterapii

    Gda?sk, 80-214, Poland

  • Wakayama Medical University Hospital

    Wakayama, 641-8510, Japan

  • Warminsko-Mazurskie Centrum Chorób P?uc w Olsztynie

    Olsztyn, 10-357, Poland

  • Weill Cornell Medical College-New York Presbyterian Hospital

    New York, New York, 10021, United States

  • West China Hospital - Sichuan University

    Chengdu, 610047, China

  • Wielkopolskie Centrum Pulmonologii i Torakochirurgii w Poznaniu

    Poznan, 60-569, Poland

  • William Osler Health System Brampton Civic Hospital

    Brampton, Ontario, L6R 3J7, Canada

  • Yonsei University Health System/Severance Hospital

    Seoul, 120-752, South Korea

  • Zhejiang Cancer Hospital

    Hangzhou, 310022, China

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