Engineered immune cells show promise against Tough-to-Treat lymphoma
NCT ID NCT03105336
First seen Jan 11, 2026 · Last updated Apr 30, 2026 · Updated 19 times
Summary
This study tested a treatment called axicabtagene ciloleucel (a CAR T-cell therapy) in 159 adults with follicular or marginal zone lymphoma that had returned or stopped responding after at least two prior treatments. The therapy works by reprogramming a patient's own immune cells to find and attack cancer cells. The main goal was to see how many patients had their tumors shrink or disappear. While this approach can control the disease, it is not a cure because patients may need ongoing monitoring or additional treatments.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Banner MD Anderson Cancer Center
Gilbert, Arizona, 85234, United States
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Centre Hospitalier Lyon Sud
Pierre-Bénite, 69495, France
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Centre Hospitalier Régional Universitaire de Lille
Lille, 59037, France
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Columbia University Medical Center
New York, New York, 10032, United States
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Dana Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Fox Chase Cancer Center
Philadelphia, Pennsylvania, 19111, United States
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Fred Hutchinson Cancer Research Center
Seattle, Washington, 98109, United States
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Georgetown Lombardi Comprehensive Cancer Center
Washington D.C., District of Columbia, 20007, United States
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H Lee Moffitt Cancer Center
Tampa, Florida, 33612, United States
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Hackensack University Medical Center - John Theurer Cancer Center
Hackensack, New Jersey, 07601, United States
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MD Anderson Cancer Center
Houston, Texas, 77030, United States
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Ohio State University Medical Center
Cleveland, Ohio, 44106, United States
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Sarah Cannon Research Institute
Nashville, Tennessee, 37203, United States
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UPMC Hillman Cancer Center
Pittsburgh, Pennsylvania, 15232, United States
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USC Norris Comprehensive Cancer Center
Los Angeles, California, 90033, United States
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University of California Los Angeles
Los Angeles, California, 90095, United States
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University of Miami Hospital and Clinics
Miami, Florida, 33136, United States
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University of Rochester Medical Center (URMC)
Rochester, New York, 14642, United States
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Vanderbilt University Medical Center
Nashville, Tennessee, 37232, United States
Conditions
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