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Pacemaker trick may reveal who needs fluids after heart surgery

NCT ID NCT07730242

Knowledge-focused Sponsor: Maastricht University Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
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Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 28, 2026 · Last updated Jul 29, 2026 · Updated 1 time

Summary

This study tests whether a simple pacing routine using a temporary pacemaker wire can help predict which patients need extra fluids after heart surgery. Researchers will gradually increase and then decrease the heart rate while measuring stroke volume changes. The goal is to see if these changes can identify fluid responsiveness before giving a standard fluid bolus.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
atrial pacing protocol via surgically placed pacemaker wire
What this could lead to
If successful, this approach could give doctors a quick, non-invasive way to tell whether a patient needs more fluids after heart surgery.
What could go wrong
This is a small, early observational study with only 18 participants. The pacing protocol may not reliably predict fluid needs in all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 18 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jan 2027

An estimate. Start dates often move.

Expected to finish

Jan 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged 18 years or older. * Underwent CABG surgery, without concomitant valve surgery. * Admitted to the ICU during the first postoperative day. * Equipped with surgically placed temporary atrial pacemaker wire. * Scheduled for a 500 mL bolus of balanced solution (Ringer's lactate) within the first two postoperative hours for clinical reasons. * Able to provide preoperative consent at the outpatient clinic before the surgery takes place. * Assessed by the attending intensivist as hemodynamically stable and (thereby) eligible for the study. Exclusion Criteria: * Presence of atrial fibrillation or other arrhythmias precluding atrial pacing. * Absence of atrial pacemaker wire. * Suspected cardiac tamponade or significant postoperative bleeding (e.g., \>400 mL blood loss in the first hour postoperatively). * Use of extracorporeal life support (ECLS) during the observation period. * Acute changes in vasopressor or inotrope dosage within the observation period. * Significant changes in body position, ventilator settings, or pacing mode during the study protocol. * Known contraindications to echocardiographic monitoring or arterial wave form analysis.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Evaluate whether beat-to-beat ramped atrial pacing is related to fluid responsiveness in postcardiac surgery patients

How to take part

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  1. The official record

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    Open the record ↗

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