Gulf study tests which blood thinner best protects hearts
NCT ID NCT07572747
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares two common blood thinners, aspirin and clopidogrel, to see which one better prevents heart attacks, strokes, and related events in people with stable heart disease. About 6,740 participants from Gulf countries will take one of the two drugs for several years. The goal is to find the most effective long-term prevention strategy.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Aspirin and clopidogrel
- What this could lead to
- If successful, this could show that clopidogrel is better than aspirin at preventing heart attacks and strokes in people with stable heart disease.
- What could go wrong
- This is a large phase 3 trial, but it hasn't started yet. Results may not apply to all patients, and both drugs carry bleeding risks.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
-
About 6,740 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
-
Apr 2027
An estimate. Start dates often move.
- Expected to finish
-
Apr 2032
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Age ≥18 years. 2. Significant coronary artery disease (coronary angiogram documentation of Left Main artery lesion ≥50% and/or lesion(s) ≥70% in other coronary arteries, and/or FFR\<0.8 or iFR\<0.9). 3. Completed at least 6 months post ACS (regardless of the bleeding risk, anti-platelet strategy, revascularization strategy "PCI, CABG, or conservative medical management only", before randomization). 4. Agreement to give written informed consent. Exclusion Criteria: 1. History of hypersensitivity to aspirin or clopidogrel. 2. Presence of non-cardiac comorbidity with life expectancy ≤2 years from randomization. 3. Plan for surgery or intervention which requires stopping antiplatelet agents ≥3 months. 4. Females with childbearing potential or breast-feeding. 5. Co-administration of contraindicated medications as follows: anticoagulants (warfarin, direct oral anticoagulants (DOACs), or chronic therapy of heparin); cytochrome P450 2C19 inhibitors (fluoxetine, moclobemid or voriconazole); probenecid; high dose of methotrexate (≥15 mg/week); lithium. 6. Inability to have a complete follow-up for up to 5 years from randomization (e.g: high possibility of travelling outside the country). 7. Inability to afford paying for Clopidogrel out-of-pocket up to 5 years from randomization (in case not being covered by the health care system).
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Chronic coronary syndrome are added.
Genom att skicka in godkänner du våra Användarvillkor
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
-
The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
-
A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can heart stent patients go home in 6 hours?
- Can a shorter course of two blood thinners keep stents safe?
- Can a shorter course of blood thinners work after Metal-Free heart balloons?
- A 7,000-Person trial asks: is lifelong aspirin necessary for older hearts?
- Can a higher dose of adenosine sharpen heart scans?
- Can a trained eye match ultrasound for heart stent placement?