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Could aspirin ease pain in kids with rare vein condition?

NCT ID NCT07663825

Symptom relief Sponsor: University Hospital, Tours Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether adding aspirin to a standard anti-inflammatory gel can reduce pain from blood clots in children aged 6 to 17 with superficial venous malformations. The trial will compare aspirin plus gel against a placebo plus gel over 14 days. Only 34 children will take part, making this a small, early investigation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Aspirin (acetylsalicylic acid) plus diclofenac gel
What this could lead to
If it works, this could point toward a standard way to manage painful clotting episodes in children with vein malformations.
What could go wrong
This is a very small, early-phase trial with only 34 children. It may not show a clear benefit, and aspirin carries risks like stomach upset or bleeding.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 34 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Oct 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

6 to 17 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 6 to 17 years * Weight ≥ 20 kg * Isolated or combined superficial venous malformation, confirmed by imaging, with the presence of phleboliths indicating the occurrence of previous superficial venous thrombosis * Complicated by acute thrombotic episodes (2 or more in the previous 12 months) * Written consent of the child's legal representatives or of the participant if over 18 years of age * Affiliation of a social security scheme * Highly effective contraception for young women of childbearing age Exclusion Criteria: * Patients with deep or syndromic venous malformation * Patients with known G6PD deficiency * Patients with known mastocytosis * History of hemarthrosis * Simultaneous participation in another biomedical study * Constitutional or acquired haemostasis pathology * Current treatment affecting haemostasis (anticoagulants, platelet anti aggregants, oral NSAIDs) * Frequent bleeding (epistaxis, other) requiring management * Basic treatment of venous malformation (mTOR inhibitor) * Active neoplasia or infection (altered coagulation balance) * Known allergy to acetylsalicylic acid * Injured skin, whatever the lesion: oozing dermatitis, eczema, infected lesions, burns or wounds * Pregnant and breastfeeding women * Severe renal insufficiency, severe hepatic insufficiency, severe uncontrolled cardiac insufficiency * Methotrexate ≥ 20 mg/week

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Conditions

The condition(s) this trial relates to.

venous hemangioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Venous malformation, low flow Venous malformations

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    6 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • AP-HM

    Marseille, France

  • AP-HP

    Paris, France

  • Centre Hospitalier Universitaire d'Angers

    Angers, France

  • Centre Hospitalier Universitaire de Brest

    Brest, France

  • Centre Hospitalier Universitaire de Nantes

    Nantes, France

  • Centre Hospitalier Universitaire de Rennes

    Rennes, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.