New drug targets common cancer mutation in first human trial

NCT ID NCT06364696

Ongoing Disease control Sponsor: Astellas Pharma Inc Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 22, 2026 · Updated 33 times

Summary

This early-stage study tests a new drug, ASP4396, in adults with advanced solid tumors that have a specific change in the KRAS gene (G12D). The main goals are to find a safe dose and check for side effects. Participants receive the drug through a vein and are closely monitored for about 45 weeks after treatment ends.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Icahn School of Medicine at Mount Sinai

New York, New York, 10029, United States
NEXT Oncology Dallas

Irving, Texas, 75039, United States
NEXT Oncology Virginia

Fairfax, Virginia, 22031, United States
START Midwest

Grand Rapids, Michigan, 49546, United States
START Mountain Region

West Valley City, Utah, 84119, United States
University of Kansas Cancer Center

Westwood, Kansas, 66205, United States
University of Rochester

Rochester, New York, 14627, United States

Conditions

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SOLID TUMOR